publication . Article . 2012

The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness

Patrizia eCampolongo; Patrizia eRatano; Antonia eManduca; Maria Luisa eScattoni; Maura ePalmery; Viviana eTrezza; Vincenzo eCuomo;
Open Access English
  • Published: 01 Mar 2012 Journal: Frontiers in Behavioral Neuroscience, volume 6 (issn: 1662-5153, eissn: 1662-5153, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Cannabinoid compounds may influence both emotional and cognitive processes depending on the level of environmental aversiveness at the time of drug administration. However, the mechanisms responsible for these responses remain to be elucidated. The present experiments investigated the effects induced by the endocannabinoid transport inhibitor AM404 (0.5-5 mg/kg, i.p.) on bothemotional and cognitive performances of rats tested in a Spatial Open Field task and subjected to different experimental settings, named High Arousal and Low Arousal conditions. The two different experimental conditions influenced emotional reactivity independently of drug administration. In...
Subjects
free text keywords: Spatial Open Field task, cognition, learning and memory, Neurosciences. Biological psychiatry. Neuropsychiatry, emotionality, RC321-571, Neuroscience, Original Research Article, endocannabinoids, cannabinoid system, short-term memory
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publication . Article . 2012

The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness

Patrizia eCampolongo; Patrizia eRatano; Antonia eManduca; Maria Luisa eScattoni; Maura ePalmery; Viviana eTrezza; Vincenzo eCuomo;