Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction

Article English OPEN
Yasuharu Shinoda ; Hideaki Tagashira ; Md. Shenuarin Bhuiyan ; Hideyuki Hasegawa ; Hiroshi Kanai ; Kohji Fukunaga (2016)
  • Publisher: Elsevier
  • Journal: Journal of Pharmacological Sciences, volume 131, issue 3, pages 172-183 (issn: 1347-8613)
  • Related identifiers: doi: 10.1016/j.jphs.2016.05.012
  • Subject: Haloperidol | Myocardial hypertrophy | RM1-950 | Therapeutics. Pharmacology | Sigma-1 receptor (σ1R) | Angiotensin II (Ang II) | ATP
    mesheuropmc: behavioral disciplines and activities

Haloperidol is an antipsychotic drug that inhibits the dopamine D2 receptor among others. Haloperidol also binds the sigma-1 receptor (σ1R) and inhibits it irreversibly. A serious outcome of haloperidol treatment of schizophrenia patients is death due to sudden cardiac ... View more
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