4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells

Article English OPEN
Suzuki, Maiko ; Everett, Eric T. ; Whitford, Gary M. ; Bartlett, John D. (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Physiology, volume 8 (issn: 1664-042X, eissn: 1664-042X)
  • Related identifiers: pmc: PMC5425599, doi: 10.3389/fphys.2017.00302/full, doi: 10.3389/fphys.2017.00302
  • Subject: QP1-981 | dental fluorosis | TGF-β1 | ER stress | 4-phenylbutyrate | Physiology | fluoride | enamel | apoptosis | Original Research | ameloblast
    mesheuropmc: stomatognathic system

Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA,... View more
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