Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity.

Article, Preprint English OPEN
Bassani-Sternberg, Michal; Chong, Chloé; Guillaume, Philippe; Solleder, Marthe; Pak, HuiSong; Gannon, Philippe O.; Kandalaft, Lana E.; Coukos, George; Gfeller, David;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Computational Biology,volume 13,issue 8 (issn: 1553-734X, eissn: 1553-7358)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pcbi.1005725, doi: 10.1101/098780, pmc: PMC5584980
  • Subject: Research Article | Amino Acids | Sequence Motif Analysis | Chemical Characterization | Peptides | Chemical Compounds | Oncology | Physical Sciences | Arginine | Organic Chemistry | Proteomes | Proteins | Sequence Analysis | Cancers and Neoplasms | Biosynthetic Techniques | Database and Informatics Methods | Peptide Synthesis | Chemistry | Biology and Life Sciences | bepress|Life Sciences|Bioinformatics | Research and Analysis Methods | Basic Amino Acids | Binding Analysis | QH301-705.5 | bepress|Life Sciences|Biology | Chemical Synthesis | Melanomas | Biochemistry | Bioinformatics | Organic Compounds | Medicine and Health Sciences | Histidine | Biology (General) | Amino Acid Motifs/genetics; Binding Sites/genetics; Histocompatibility Antigens Class I/chemistry; Histocompatibility Antigens Class I/genetics; Histocompatibility Antigens Class I/metabolism; Humans; Peptides/analysis; Peptides/chemistry; Peptides/genetics; Peptides/metabolism; Protein Binding/genetics; Proteome/chemistry; Proteome/genetics; Proteome/metabolism; Proteomics/methods

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten... View more
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