publication . Article . 2011

Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies.

Talmud, P. J.; Cooper, J. A.; Gaunt, T.; Holmes, M. V.; Shah, S.; Palmen, J.; Drenos, F.; Shah, T.; Kumari, M.; Kivimaki, M.; ...
Open Access English
  • Published: 01 Apr 2011
  • Publisher: Springer Verlag
  • Country: United Kingdom
Abstract
Aims/hypothesis We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. Methods Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 diabetes cases) with regard to metabolic traits and type 2 diabetes risk. Two studies (n = 9,437), genotyped using the Human Cardiovascular Disease BeadChip, provided 12 additional ADRA2A SNPs. Results Rs553668 was associated with per allele effects on fasting glucose (0.03 mmol/l, p = 0.016) and type 2 diabetes risk (OR 1.17, 95% CI 1.04–1.31; p = 0....
Subjects
free text keywords: Article, ADRA2A, α-2 Adrenergic receptor, Fasting glucose, Human CVD BeadChip, Meta-analysis, Prospective studies, rs553668, rs10885122, TCF7L2, Type 2 diabetes mellitus, Internal Medicine, Endocrinology, Diabetes and Metabolism, Obesity, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Body mass index, Type 2 diabetes, Risk factor, Diabetes mellitus, Blood pressure, Biology
Funded by
NIH| English Longitudinal Study of Ageing
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01AG017644-14S2
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R37AG013196-07
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| SOCIAL AND OCCUPATIONAL INFLUENCES ON HEALTH AND ILLNESS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL036310-09
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
RCUK| Public health applications of cardiovascular genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0802432
  • Funding stream: MRC
Abstract
Aims/hypothesis We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. Methods Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 were analysed in >17,000 individuals (1,307 type 2 diabetes cases) with regard to metabolic traits and type 2 diabetes risk. Two studies (n = 9,437), genotyped using the Human Cardiovascular Disease BeadChip, provided 12 additional ADRA2A SNPs. Results Rs553668 was associated with per allele effects on fasting glucose (0.03 mmol/l, p = 0.016) and type 2 diabetes risk (OR 1.17, 95% CI 1.04–1.31; p = 0....
Subjects
free text keywords: Article, ADRA2A, α-2 Adrenergic receptor, Fasting glucose, Human CVD BeadChip, Meta-analysis, Prospective studies, rs553668, rs10885122, TCF7L2, Type 2 diabetes mellitus, Internal Medicine, Endocrinology, Diabetes and Metabolism, Obesity, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, Body mass index, Type 2 diabetes, Risk factor, Diabetes mellitus, Blood pressure, Biology
Funded by
NIH| English Longitudinal Study of Ageing
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R01AG017644-14S2
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R37AG013196-07
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| SOCIAL AND OCCUPATIONAL INFLUENCES ON HEALTH AND ILLNESS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01HL036310-09
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
RCUK| Public health applications of cardiovascular genomics
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G0802432
  • Funding stream: MRC
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