Effects of Humidity and Surfaces on the Melt Crystallization of Ibuprofen

Other literature type, Article English OPEN
Lee, Dong-Joo ; Lee, Suyang ; Kim, Il Won (2012)
  • Publisher: Molecular Diversity Preservation International
  • Journal: International Journal of Molecular Sciences, volume 13, issue 8, pages 10,296-10,304 (issn: 1422-0067, eissn: 1422-0067)
  • Related identifiers: doi: 10.3390/ijms130810296, pmc: PMC3431859
  • Subject: Chemistry | melt | surfaces | QD1-999 | crystallization | ibuprofen | humidity | crystallization; ibuprofen; melt; humidity; surfaces | Article | Biology (General) | QH301-705.5

Melt crystallization of ibuprofen was studied to understand the effects of humidity and surfaces. The molecular self-assembly during the amorphous-to-crystal transformation was examined in terms of the nucleation and growth of the crystals. The crystallization was on Al... View more
  • References (21)
    21 references, page 1 of 3

    Bernstein, J. Polymorphism in Molecular Crystals, 1st ed.; Oxford University Press: Oxford, UK, 2002.

    Buckley, H.E. Crystal Growth, 3rd ed.; John Wiley & Sons: New York, NY, USA, 1951; pp. 339-387.

    Kim, I.W.; Collino, S.; Evans, J.S. Cooperative modulation of mineral growth by prismatic-associated asprich sequences and Mg(II). Int. J. Mol. Sci. 2012, 13, 3949-3958.

    Mullin, J.W. Crystallization, 4th ed.; Butterworth-Heinemann: Oxford, UK, 2001; pp. 32-85.

    Blagden, N.; de Matas, M.; Gavan, P.T.; York, P. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv. Drug Deliv. Rev. 2007, 56, 617-630.

    6. Rodríguez-Spong, B.; Price, C.P.; Jayasankar, A.; Matzger, A.J.; Rodríguez-Hornedo, N. General principles of pharmaceutical solid polymorphism: A supramolecular perspective. Adv. Drug Deliv. Rev. 2004, 56, 241-274.

    7. Chow, K.; Tong, H.H.Y.; Lum, S.; Chow, A.H.L. Engineering of pharmaceutical materials: An industrial perspective. J. Pharm. Sci. 2008, 97, 2855-2877.

    8. Lee, M.K.; Lee, H.; Kim, I.W.; Lee, J. Novel polymorphic form of adefovir dipivoxil derived from polymer-directed crystallization. Pharmazie 2011, 66, 766-770.

    9. Gu, C.-H.; Grant, D.J.W. Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data. J. Pharm. Sci. 2001, 90, 1277-1287.

    10. Shegokar, R.; Müller, R. Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives. Int. J. Pharm. 2010, 399, 129-139.

  • Metrics
    No metrics available
Share - Bookmark