A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan

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Hachinohe, Mayumi ; Yamane, Midori ; Akazawa, Daiki ; Ohsawa, Kazuhiro ; Ohno, Mayumi ; Terashita, Yuzu ; Masumoto, Hiroshi (2013)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 8, issue 1, page e54011 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0054011, pmc: PMC3544673
  • Subject: Research Article | Biology | Molecular Cell Biology | Cell Death | Energy-Producing Processes | Enzymes | Medicine | Saccharomyces Cerevisiae | Q | R | ゲノム科学 | Genetics | Bioenergetics | Model Organisms | Proteins | Science | Biochemistry | Yeast and Fungal Models | Dehydrogenases | Metabolism | Enzyme Classes | Metabolic Pathways

The regulation of energy metabolism, such as calorie restriction (CR), is a major determinant of cellular longevity. Although augmented gluconeogenesis is known to occur in aged yeast cells, the role of enhanced gluconeogenesis in aged cells remains undefined. Here, we ... View more
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