Ocular Toxicity Secondary to Asclepias physocarpa: The Balloon Plant

Article, Report English OPEN
Pina, Susana ; Pedrosa, Catarina ; Santos, Cristina ; Feijóo, Bernardo ; Pego, Peter ; Vendrell, Cristina ; Santos, Maria João ; Prieto, Isabel (2014)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Case Reports in Ophthalmological Medicine, volume 2,014 (issn: 2090-6722, eissn: 2090-6730)
  • Related identifiers: doi: 10.1155/2014/829469, pmc: PMC4101946
  • Subject: RE1-994 | Case Report | Ophthalmology | Article Subject

We report a case of a 65-year-old woman with symptoms of blurred vision and ocular irritation a few hours after accidental contact of the right eye with Asclepias physocarpa milky latex. Observation showed a diffuse conjunctival hyperemia and stromal corneal edema with Descemet’s membrane folds. Recovery was fast and apparently complete in less than one month. However, specular microscopy at 6-months follow-up showed an abnormal endothelial morphology as sequelae, suggesting this condition is not as innocuous as it has been suggested.
  • References (8)

    [1] M. D. Amiran, Y. Lang, and S. N. Yeung, “Corneal endothelial toxicity secondary to Asclepias fruticosa,” Eye, vol. 25, no. 7, pp. 961-963, 2011.

    [2] S. Chakraborty, J. Siegenthaler, and E. R. Buchi, “Corneal edema due to Asclepias curassavica,” Archives of Ophthalmology, vol. 113, no. 8, pp. 974-975, 1995.

    [3] J. Joubert, “Cardiac glycosides,” in Toxicants of Plant Origin: Glycosides, P. R. Cheeke, Ed., vol. 2, pp. 61-96, CRC Press, Boca Raton, Fla, USA, 1989.

    [4] A. J. Abbott, C. G. Holoubek, and R. A. Martin, “Inhibition of Na+,K+-ATPase by the cardenolide 6 -O-(E-4-hydroxycinnamoyl) desglucouzarin,” Biochemical and Biophysical Research Communications, vol. 251, no. 1, pp. 256-259, 1998.

    [5] D. G. Dawson, M. A. Watsky, D. H. Geroski, and H. F. Edelhauser, “Chapter 4: cornea and sclera,” in Duane's Foundations of Clinical Ophthalmology, W. M. D. Tasman, Ed., vol. 2, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2006.

    [6] S. Hatou, M. Yamada, H. Mochizuki, A. Shiraishi, T. Joko, and T. Nishida, “eTh eefcts of dexamethasone on the Na,K-ATPase activity and pump function of corneal endothelial cells,” Current Eye Research, vol. 34, no. 5, pp. 347-354, 2009.

    [7] B. E. McCarey, H. F. Edelhauser, and M. J. Lynn, “Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions,” Cornea, vol. 27, no. 1, pp. 1-16, 2008.

    [8] W. M. Bourne, “Biology of the corneal endothelium in health and disease,” Eye, vol. 17, no. 8, pp. 912-918, 2003.

  • Metrics
    No metrics available
Share - Bookmark