The Anti-Apoptotic Activity of BAG3 Is Restricted by Caspases and the Proteasome

Article English OPEN
Virador, Victoria M. ; Davidson, Ben ; Czechowicz, Josephine ; Mai, Alisha ; Kassis, Jareer ; Kohn, Elise C. (2009)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 4, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC2662420, doi: 10.1371/journal.pone.0005136
  • Subject: Q | R | Research Article | Cell Biology | Science | Cell Biology/Cellular Death and Stress Responses | Medicine | Biochemistry/Cell Signaling and Trafficking Structures

Background Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as A... View more
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