Robust and Accurate Discrimination of Self/Non-Self Antigen Presentations by Regulatory T Cell Suppression

Article English OPEN
Chikara Furusawa; Tomoyuki Yamaguchi;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 11,issue 9 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0163134, pmc: PMC5036821
  • Subject: Immune System Proteins | Research Article | Antigen Presentation | Regulatory T cells | Chemical Dissociation | Cell Processes | Chemical Reactions | T Cell Receptors | Physical Sciences | White Blood Cells | Immune Response | Proteins | Immune System | Immunology | Chemistry | Cellular Types | Biology and Life Sciences | Antigen-Presenting Cells | Signal Transduction | Blood Cells | Immune Cells | Medicine | Animal Cells | Innate Immune System | Q | R | Cell Biology | T Cells | Science | Biochemistry | Medicine and Health Sciences | Immune Receptors | Cell Cycle and Cell Division

The immune response by T cells usually discriminates self and non-self antigens, even though the negative selection of self-reactive T cells is imperfect and a certain fraction of T cells can respond to self-antigens. In this study, we construct a simple mathematical mo... View more
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