publication . Article . Other literature type . 2009

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism

Perttilä, Julia; Merikanto, Krista; Naukkarinen, Jussi; Surakka, Ida; Martin, Nicolas W.; Tanhuanpää, Kimmo; Grimard, Vinciane; Taskinen, Marja-Riitta; Thiele, Christoph; Salomaa, Veikko; ...
Open Access English
  • Published: 25 Jun 2009 Journal: Journal of Molecular Medicine, volume 87, issue 8, pages 825-835 (issn: 0946-2716, Copyright policy)
  • Publisher: Springer Nature
  • Country: Belgium
Abstract
info:eu-repo/semantics/published
Subjects
free text keywords: Biochimie, Cell Line, Tumor, Cholesterol, HDL -- blood -- genetics -- metabolism, Female, Finland, Gene Silencing, Hepatocytes -- metabolism, Humans, Hyperlipidemia, Familial Combined -- genetics -- metabolism, Male, Microtubules -- chemistry, Polymorphism, Single Nucleotide, Receptors, Steroid -- analysis -- genetics -- metabolism, Triglycerides -- blood -- genetics -- metabolism, Genetics(clinical), Molecular Medicine, Drug Discovery, Medicine(all), Original Article, Microtubule, Oxysterol-binding protein, Single-nucleotide polymorphism, Candidate gene, Endocrinology, medicine.medical_specialty, medicine, High-density lipoprotein, chemistry.chemical_compound, chemistry, Triglyceride, Internal medicine, Lipoprotein, Apolipoprotein B, biology.protein, biology, Lipogenesis, Lipid metabolism, Cholesterol
32 references, page 1 of 3

1. Fairn GD McMaster CR Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling Cell Mol Life Sci 2007 65 228 236 10.1007/s00018-007-7325-2 Fairn GD, McMaster CR (2007) Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling. Cell Mol Life Sci 65:228–236 17938859 [OpenAIRE] [PubMed] [DOI]

2. Yan D Olkkonen VM Characteristics of oxysterol binding proteins Int Rev Cytol 2008 265 253 285 10.1016/S0074-7696(07)65007-4 Yan D, Olkkonen VM (2008) Characteristics of oxysterol binding proteins. Int Rev Cytol 265:253–285 18275891 [OpenAIRE] [PubMed] [DOI]

3. Jaworski CJ Moreira E Li A Lee R Rodriguez IR A family of 12 human genes containing oxysterol-binding domains Genomics 2001 78 185 196 10.1006/geno.2001.6663 Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (2001) A family of 12 human genes containing oxysterol-binding domains. Genomics 78:185–196 11735225 [OpenAIRE] [PubMed] [DOI]

4. Lehto M Laitinen S Chinetti G Johansson M Ehnholm C Staels B Ikonen E Olkkonen VM The OSBP-related protein family in humans J Lipid Res 2001 42 1203 1213 Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (2001) The OSBP-related protein family in humans. J Lipid Res 42:1203–1213 11483621 [OpenAIRE] [PubMed]

5. Perry RJ Ridgway ND Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein Mol Biol Cell 2006 17 2604 2616 10.1091/mbc.E06-01-0060 Perry RJ, Ridgway ND (2006) Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol Biol Cell 17:2604–2616 16571669 [OpenAIRE] [PubMed] [DOI]

6. Wang PY Weng J Anderson RG OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation Science 2005 307 1472 1476 10.1126/science.1107710 Wang PY, Weng J, Anderson RG (2005) OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science 307:1472–1476 15746430 [OpenAIRE] [PubMed] [DOI]

7. Yan D Lehto M Rasilainen L Metso J Ehnholm C Ylä-Herttuala S Jauhiainen M Olkkonen VM Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis Arterioscler Thromb Vasc Biol 2007 27 1108 1114 10.1161/ATVBAHA.106.138545 Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, Ylä-Herttuala S, Jauhiainen M, Olkkonen VM (2007) Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Arterioscler Thromb Vasc Biol 27:1108–1114 17303778 [OpenAIRE] [PubMed] [DOI]

8. Yan D Jauhiainen M Hildebrand RB Willems van Dijk K Berkel TJ Ehnholm C Eck M Olkkonen VM Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice Arterioscler Thromb Vasc Biol 2007 27 1618 1624 10.1161/ATVBAHA.107.144121 Yan D, Jauhiainen M, Hildebrand RB, Willems van Dijk K, Van Berkel TJ, Ehnholm C, Van Eck M, Olkkonen VM (2007) Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 27:1618–1624 17478758 [OpenAIRE] [PubMed] [DOI]

9. Yan D Mäyränpää MI Wong J Perttilä J Lehto M Jauhiainen M Kovanen PT Ehnholm C Brown AJ Olkkonen VM OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macro phages J Biol Chem 2007 283 332 340 10.1074/jbc.M705313200 Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (2007) OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem 283:332–340 17991739 [OpenAIRE] [PubMed] [DOI]

10.Hynynen R, Suchanek M, Spandl J, Back N, Thiele C, Olkkonen VM (2009) OSBP-related protein 2 (ORP2) is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. J Lipid Res 50:1305–1315

11. Ngo M Ridgway ND Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function Mol Biol Cell 2009 20 1388 1399 10.1091/mbc.E08-09-0905 Ngo M, Ridgway ND (2009) Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. Mol Biol Cel l 20:1388–1399 19129476 [OpenAIRE] [PubMed] [DOI]

12. Wang C JeBailey L Ridgway ND Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments Biochem J 2002 361 461 472 10.1042/0264-6021:3610461 Wang C, JeBailey L, Ridgway ND (2002) Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. Biochem J 361:461–472 11802775 [OpenAIRE] [PubMed] [DOI]

13. Genest JJ Jr Martin-Munley SS McNamara JR Ordovas JM Jenner J Myers RH Silberman SR Wilson PW Salem DN Schaefer EJ Familial lipoprotein disorders in patients with premature coronary artery disease Circulation 1992 85 2025 2033 Genest JJ Jr, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH, Silberman SR, Wilson PW, Salem DN, Schaefer EJ (1992) Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 85:2025–2033 1534286 [OpenAIRE] [PubMed]

14. Goldstein JL Schrott HG Hazzard WR Bierman EL Motulsky AG Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia J Clin Invest 1973 52 1544 1568 10.1172/JCI107332 Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG (1973) Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 52:1544–1568 4718953 [OpenAIRE] [PubMed] [DOI]

15. Nikkilä EA Aro A Family study of serum lipids and lipoproteins in coronary heart-disease Lancet 1973 1 954 959 10.1016/S0140-6736(73)91598-5 Nikkilä EA, Aro A (1973) Family study of serum lipids and lipoproteins in coronary heart-disease. Lancet 1:954–959 4121585 [PubMed] [DOI]

32 references, page 1 of 3
Abstract
info:eu-repo/semantics/published
Subjects
free text keywords: Biochimie, Cell Line, Tumor, Cholesterol, HDL -- blood -- genetics -- metabolism, Female, Finland, Gene Silencing, Hepatocytes -- metabolism, Humans, Hyperlipidemia, Familial Combined -- genetics -- metabolism, Male, Microtubules -- chemistry, Polymorphism, Single Nucleotide, Receptors, Steroid -- analysis -- genetics -- metabolism, Triglycerides -- blood -- genetics -- metabolism, Genetics(clinical), Molecular Medicine, Drug Discovery, Medicine(all), Original Article, Microtubule, Oxysterol-binding protein, Single-nucleotide polymorphism, Candidate gene, Endocrinology, medicine.medical_specialty, medicine, High-density lipoprotein, chemistry.chemical_compound, chemistry, Triglyceride, Internal medicine, Lipoprotein, Apolipoprotein B, biology.protein, biology, Lipogenesis, Lipid metabolism, Cholesterol
32 references, page 1 of 3

1. Fairn GD McMaster CR Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling Cell Mol Life Sci 2007 65 228 236 10.1007/s00018-007-7325-2 Fairn GD, McMaster CR (2007) Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling. Cell Mol Life Sci 65:228–236 17938859 [OpenAIRE] [PubMed] [DOI]

2. Yan D Olkkonen VM Characteristics of oxysterol binding proteins Int Rev Cytol 2008 265 253 285 10.1016/S0074-7696(07)65007-4 Yan D, Olkkonen VM (2008) Characteristics of oxysterol binding proteins. Int Rev Cytol 265:253–285 18275891 [OpenAIRE] [PubMed] [DOI]

3. Jaworski CJ Moreira E Li A Lee R Rodriguez IR A family of 12 human genes containing oxysterol-binding domains Genomics 2001 78 185 196 10.1006/geno.2001.6663 Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR (2001) A family of 12 human genes containing oxysterol-binding domains. Genomics 78:185–196 11735225 [OpenAIRE] [PubMed] [DOI]

4. Lehto M Laitinen S Chinetti G Johansson M Ehnholm C Staels B Ikonen E Olkkonen VM The OSBP-related protein family in humans J Lipid Res 2001 42 1203 1213 Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, Staels B, Ikonen E, Olkkonen VM (2001) The OSBP-related protein family in humans. J Lipid Res 42:1203–1213 11483621 [OpenAIRE] [PubMed]

5. Perry RJ Ridgway ND Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein Mol Biol Cell 2006 17 2604 2616 10.1091/mbc.E06-01-0060 Perry RJ, Ridgway ND (2006) Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol Biol Cell 17:2604–2616 16571669 [OpenAIRE] [PubMed] [DOI]

6. Wang PY Weng J Anderson RG OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation Science 2005 307 1472 1476 10.1126/science.1107710 Wang PY, Weng J, Anderson RG (2005) OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science 307:1472–1476 15746430 [OpenAIRE] [PubMed] [DOI]

7. Yan D Lehto M Rasilainen L Metso J Ehnholm C Ylä-Herttuala S Jauhiainen M Olkkonen VM Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis Arterioscler Thromb Vasc Biol 2007 27 1108 1114 10.1161/ATVBAHA.106.138545 Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, Ylä-Herttuala S, Jauhiainen M, Olkkonen VM (2007) Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Arterioscler Thromb Vasc Biol 27:1108–1114 17303778 [OpenAIRE] [PubMed] [DOI]

8. Yan D Jauhiainen M Hildebrand RB Willems van Dijk K Berkel TJ Ehnholm C Eck M Olkkonen VM Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice Arterioscler Thromb Vasc Biol 2007 27 1618 1624 10.1161/ATVBAHA.107.144121 Yan D, Jauhiainen M, Hildebrand RB, Willems van Dijk K, Van Berkel TJ, Ehnholm C, Van Eck M, Olkkonen VM (2007) Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 27:1618–1624 17478758 [OpenAIRE] [PubMed] [DOI]

9. Yan D Mäyränpää MI Wong J Perttilä J Lehto M Jauhiainen M Kovanen PT Ehnholm C Brown AJ Olkkonen VM OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macro phages J Biol Chem 2007 283 332 340 10.1074/jbc.M705313200 Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (2007) OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem 283:332–340 17991739 [OpenAIRE] [PubMed] [DOI]

10.Hynynen R, Suchanek M, Spandl J, Back N, Thiele C, Olkkonen VM (2009) OSBP-related protein 2 (ORP2) is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. J Lipid Res 50:1305–1315

11. Ngo M Ridgway ND Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function Mol Biol Cell 2009 20 1388 1399 10.1091/mbc.E08-09-0905 Ngo M, Ridgway ND (2009) Oxysterol binding protein-related Protein 9 (ORP9) is a cholesterol transfer protein that regulates Golgi structure and function. Mol Biol Cel l 20:1388–1399 19129476 [OpenAIRE] [PubMed] [DOI]

12. Wang C JeBailey L Ridgway ND Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments Biochem J 2002 361 461 472 10.1042/0264-6021:3610461 Wang C, JeBailey L, Ridgway ND (2002) Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments. Biochem J 361:461–472 11802775 [OpenAIRE] [PubMed] [DOI]

13. Genest JJ Jr Martin-Munley SS McNamara JR Ordovas JM Jenner J Myers RH Silberman SR Wilson PW Salem DN Schaefer EJ Familial lipoprotein disorders in patients with premature coronary artery disease Circulation 1992 85 2025 2033 Genest JJ Jr, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH, Silberman SR, Wilson PW, Salem DN, Schaefer EJ (1992) Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 85:2025–2033 1534286 [OpenAIRE] [PubMed]

14. Goldstein JL Schrott HG Hazzard WR Bierman EL Motulsky AG Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia J Clin Invest 1973 52 1544 1568 10.1172/JCI107332 Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG (1973) Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 52:1544–1568 4718953 [OpenAIRE] [PubMed] [DOI]

15. Nikkilä EA Aro A Family study of serum lipids and lipoproteins in coronary heart-disease Lancet 1973 1 954 959 10.1016/S0140-6736(73)91598-5 Nikkilä EA, Aro A (1973) Family study of serum lipids and lipoproteins in coronary heart-disease. Lancet 1:954–959 4121585 [PubMed] [DOI]

32 references, page 1 of 3
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