Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells

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Wang, Dan-Dan ; Jin, Yan ; Wang, Chao ; Kim, Yeon-Ju ; Perez, Zuly Elizabeth Jimenez ; Baek, Nam In ; Mathiyalagan, Ramya ; Markus, Josua ; Yang, Deok-Chun (2016)
  • Publisher: Elsevier
  • Journal: Journal of Ginseng Research, volume 42, issue 1, pages 42-49 (issn: 1226-8453, eissn: 2093-4947)
  • Related identifiers: doi: 10.1016/j.jgr.2016.12.009, pmc: PMC5766694
  • Subject: B16BL6 cell line | Research Article | melanogenesis | Botany | ginsenoside Ia | QK1-989 | UDP-glycosyltransferase | ginsenoside F1

Background: Ginsenoside F1 has been described to possess skin-whitening effects on humans. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransf... View more
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