Pathogen selection drives nonoverlapping associations between HLA loci

Article, Other literature type English OPEN
Penman, B. S.; Ashby, B.; Buckee, C. O.; Gupta, S.;
  • Publisher: National Academy of Sciences
  • Journal: Proceedings of the National Academy of Sciences of the United States,volume 110,pages19,645-19,650 (issn: 0027-8424)
  • Related identifiers: doi: 10.1073/pnas.1304218110, pmc: PMC3845180
  • Subject: Biological Sciences
    mesheuropmc: food and beverages

Pathogen-mediated selection is commonly invoked as an explanation for the exceptional polymorphism of the HLA gene cluster, but its role in generating and maintaining linkage disequilibrium between HLA loci is unclear. Here we show that pathogen-mediated selection can p... View more