PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages

Article English OPEN
Ishizuka, Edson K.; Filgueiras, Luciano Ribeiro; Rios, Francisco J.; Serezani, Carlos H.; Jancar, Sonia;

Platelet-activating factor receptor (PAFR) is a G protein-coupled receptor (GPCR) implicated in many diseases. Toll-like receptors (TLRs) play a critical role in shaping innate and adaptive immune responses. In this study, we investigated whether PAFR signaling changes ... View more
  • References (55)
    55 references, page 1 of 6

    1. Wynn, T. A., Chawla, A. & Pollard, J. W. Macrophage biology in development, homeostasis and disease. Nature 496, 445-455, doi: 10.1038/nature12034 (2013).

    2. Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820, doi: 10.1016/j.cell.2010.01.022 (2010).

    3. Brubaker, S. W., Bonham, K. S., Zanoni, I. & Kagan, J. C. Innate immune pattern recognition: a cell biological perspective. Annu. Rev. Immunol. 33, 257-290, doi: 10.1146/annurev-immunol-032414-112240 (2015).

    4. Silverstein, R. L. & Febbraio, M. CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci. Signal. 2, re3, doi: 10.1126/scisignal.272re3 (2009).

    5. Bingham, C. O. & Austen, K. F. Phospholipase A2 enzymes in eicosanoid generation. Proc. Assoc. Am. Physicians 111, 516-524 (1999).

    6. Prescott, S. M., Zimmerman, G. A., Staofrini, D. M. & McIntyre, T. M. Platelet-activating factor and related lipid mediators. Annu. Rev. Biochem. 69, 419-445, doi: 10.1146/annurev.biochem.69.1.419 (2000).

    7. Rios, F. J. et al. Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. PLoS One 8, e76893, doi: 10.1371/journal.pone.0076893 (2013).

    8. Ferracini, M., Rios, F. J., Pecenin, M. & Jancar, S. Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of CD36 and platelet-activating factor receptor. Mediators Inaflmm . 2013, 950273, doi: 10.1155/2013/950273 (2013).

    9. Fleming, B. D. & Mosser, D. M. Regulatory macrophages: setting the threshold for therapy. Eur. J. Immunol. 41, 2498-2502, doi: 10.1002/eji.201141717 (2011).

    10. O'Neill, L. A., Golenbock, D. & Bowie, A. G. eTh history of Toll-like receptors-redefining innate immunity. Nat. Rev. Immunol. 13, 453-460, doi: 10.1038/nri3446 (2013).

  • Related Research Results (1)
  • Related Organizations (7)
  • Metrics