Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160

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Perrin, Arnaud; Rousseau, Joël; Tremblay, Jacques P.;
  • Publisher: American Society of Gene & Cell Therapy
  • Journal: Molecular Therapy. Nucleic Acids, volume 6, pages 68-79 (issn: 2162-2531, eissn: 2162-2531)
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  • Identifiers: pmc: PMC5363410, doi: 10.1016/j.omtn.2016.11.004
  • Subject: Original Article | transcription factor | induction of transcription | RM1-950 | transcription | Therapeutics. Pharmacology | Duchenne muscular dystrophy | DMD | CRISPR/Cas9 | laminin-111 | dCas9-VP160

Laminin-111 protein complex links the extracellular matrix to integrin α7β1 in sarcolemma, thus replacing in dystrophic muscles links normally insured by the dystrophin complex. Laminin-111 injection in mdx mouse stabilized sarcolemma, restored serum creatine kinase to ... View more
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