Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene

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Zhang, Qunfeng; Du, Yiqiao; Zhang, Xinju; Kang, Zhihua; Guan, Ming; Wu, Zhiyuan;
(2018)

Background. KRAS genotyping in tumor samples is a decisive clinical test for the anti-EGFR therapy management. However, the complexity of KRAS mutation landscape across different cancer types and the mosaic effect caused by cancer cellularity and heterogeneity make the ... View more
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