Dispatched and Scube mediate the efficient secretion of the cholesterol-modified Hedgehog ligand

Article, Other literature type English OPEN
Tukachinsky, Hanna; Kuzmickas, Ryan P.; Jao, Cindy Y.; Liu, Jing; Salic, Adrian;

The Hedgehog signaling pathway plays critical roles in metazoan development and in cancer. How the Hedgehog ligand is secreted and spreads to distant cells is unclear, given its covalent modification with a hydrophobic cholesterol molecule, which makes it stick to membr... View more
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