A novel RNA editing sensor tool and a specific agonist determine neuronal protein expression of RNA-edited glycine receptors and identify a genomic APOBEC1 dimorphism as a new genetic risk factor of epilepsy

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Kankowski, Svenja; Förstera, Benjamin; Winkelmann, Aline; Knauff, Pina; Wanker, Erich E.; You, Xintian A.; Semtner, Marcus; Hetsch, Florian; Meier, Jochen C.;
  • Publisher: Frontiers Research Foundation (U.S.A.)
  • Journal: volume 10issn: 1662-5099, eissn: 1662-5099
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5768626, doi: 10.3389/fnmol.2017.00439/full, doi: 10.3389/fnmol.2017.00439
  • Subject: epilepsy | ligands | glycine receptors | temporal lobe | hippocampus | Neurosciences. Biological psychiatry. Neuropsychiatry | Neuroscience | RC321-571 | Veröffentlichung der TU Braunschweig | RNA editing | Medizin | Publikationsfonds der TU Braunschweig | glycine receptors, epilepsy, temporal lobe, RNA editing, hippocampus, ligands | Original Research | Function and Dysfunction of the Nervous System
    • ddc: ddc:57 | ddc:5 | ddc:610 | ddc:576

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools th... View more
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