Alternative Polyadenylation of Tumor Suppressor Genes in Small Intestinal Neuroendocrine Tumors

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Rehfeld, Anders ; Plass, Mireya ; Døssing, Kristina ; Knigge, Ulrich ; Kjær, Andreas ; Krogh, Anders ; Friis-Hansen, Lennart (2014)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Endocrinology, volume 5 (issn: 1664-2392, eissn: 1664-2392)
  • Related identifiers: pmc: PMC3995063, doi: 10.3389/fendo.2014.00046
  • Subject: molecular biology | polyadenylation | gene transcription | Original Research | neuroendocrine tumors | Endocrinology | carcinoids
    mesheuropmc: education | psychological phenomena and processes | mental disorders

The tumorigenesis of small intestinal neuroendocrine tumors (SI-NETs) is poorly understood. Recent studies have associated alternative polyadenylation (APA) with proliferation, cell transformation, and cancer. Polyadenylation is the process in which the pre-messenger RN... View more
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