publication . Article . Other literature type . 2017

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Name: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Article

Meera Hameed; Ryma Benayed; Jaclyn F. Hechtman; Ahmet Zehir; Meera Prasad; Hongxin Zhang; Laetitia Borsu; Nikolaus Schultz; David Barron; Sarah Phillips; ...

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Open Access

Published: 08 May 2017 Journal: Nature Medicine, volume 23, pages 703-713 (issn: 1078-8956, eissn: 1546-170X,

Publisher: Springer Science and Business Media LLC

Summary
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Abstract

Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically-defined tumor types, coupled with an expanding portfolio of molecularly-targeted therapies, demands flexible and comprehensive approaches to profile clinically significant genes across the full spectrum of cancers. We established a large-scale, prospective clinical sequencing initiative utilizing a comprehensive assay, MSK-IMPACT, through which we have compiled matched tumor and normal sequence data...

doi: 10.1038/nm.4333

pmc: PMC5461196

pmid: 28481359

Subjects

free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Article, Cancer, medicine.disease, medicine, Genomics, Clinical trial, Prospective cohort study, Bioinformatics, Computational biology, Biology, Biomarker (medicine), Gene, Mutation, medicine.disease_cause, Sequence analysis

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

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NIH| MOUSE GENETICS

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http://dx.doi.org/10.1038/nm.4...

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