2D QSAR studies of the inhibitory activity of a series of substituted purine derivatives against c-Src tyrosine kinase

Article English OPEN
Mukesh C. Sharma (2016)
  • Publisher: Taylor & Francis Group
  • Journal: Journal of Taibah University for Science, volume 10, issue 4, pages 563-570 (issn: 1658-3655)
  • Related identifiers: doi: 10.1016/j.jtusci.2015.11.002
  • Subject: c-Src tyrosine kinase | Science (General) | Q1-390 | Purine | 2D descriptors | Quantitative structure activity relationship (QSAR) | Partial least squares (PLS)

A series of 34 substituted purine analogues derivatives were subjected to quantitative structure-activity relationship analyses as inhibitors of c-Src tyrosine kinase. Partial least squares regression was applied to derive QSAR models, which were further validated for s... View more
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