A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

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Pothlichet, Julien; Niewold, Timothy B; Vitour, Damien; Solhonne, Brigitte; Crow, Mary K; Si-Tahar, Mustapha;

Dysregulation of the antiviral immune response may contribute to autoimmune diseases. Here, we hypothesized that altered expression or function of MAVS, a key molecule downstream of the viral sensors RIG-I and MDA-5, may impair antiviral cell signalling and thereby infl... View more
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