publication . Preprint . 2016


Vladimir Ivošev; Gloria Jiménez Sánchez; Darine Abi Haidar; Rana Bazzi; Stéphane Roux; Sandrine Lacombe;
Open Access English
  • Published: 08 Dec 2016
  • Publisher: Cold Spring Harbor Laboratory
<jats:title>Abstract</jats:title><jats:p>Cancer is one of the leading causes of death. Radiation therapy is an important modality used in cancer treatment being highly cost-effective. Major flaw of radiotherapy is lack of selectivity between cancerous and healthy tissues. Amelioration of radiotherapy by using high-Z nanoparticles as radiation enhancers is one of potential solutions. Gold nanoparticles (AuNPs) are commonly used as radioenhancers. Understanding the interaction between cancer cells and AuNPs is essential in order to achieve best possible radioenhancing effects, while sparing healthy tissues. This work aims to elucidate interactions of ultrasmall (c...
free text keywords: Colloidal gold, Biophysics, Cancer cell, Bioinformatics, Cancer, medicine.disease, medicine, Biology, Internalization, media_common.quotation_subject, media_common, Radiation therapy, medicine.medical_treatment, In vitro, Cell, medicine.anatomical_structure, Nanoparticle
Funded by
Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies
  • Funder: European Commission (EC)
  • Project Code: 608163
  • Funding stream: FP7 | SP3 | PEOPLE
46 references, page 1 of 4

Jemal, A., Bray, F. & Ferlay, J. Global Cancer Statistics: 2011. CA Cancer J Clin 49, 1,33-64 (1999).

Section, S. Global Cancer. Society 1-57 (2008). doi:10.1002/ijc.27711 Delaney, G., Jacob, S., Featherstone, C. & Barton, M. The role of radiotherapy in cancer treatment: Estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer 104, 1129- 1137 (2005).

Cancer 11, 239-253 (2011).

Barnett, G. C., West, C. M. L., Dunning, A. M. & Burnet, N. G. UKPMC Funders Group Normal tissue reactions to radiotherapy : 9, 134-142 (2009).

Reports Pract. Oncol. Radiother. 15, 176-180 (2010).

Nanomedicine Nanotechnology, Biol. Med. 10, 1601-1608 (2014).

Br. J. Radiol. 87, 1-15 (2014).

Hainfeld, J. F., Slatkin, D. N. & Smilowitz, H. M. The use of gold nanoparticles to enhance radiotherapy in mice. Phys. Med. Biol. 49, N309-N315 (2004). [OpenAIRE]

Hainfeld, J. F., Smilowitz, H. M., O'Connor, M. J., Dilmanian, F. A. & Slatkin, D. N. Gold nanoparticle imaging and radiotherapy of brain tumors in mice. Nanomedicine (Lond). 8, 1601-9 (2013).

Miladi, I. et al. The in vivo radiosensitizing effect of gold nanoparticles based mri contrast agents. Small 10, 1116-1124 (2014). [OpenAIRE]

Laurent, G. et al. Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization. Nanoscale 8, 12054-12065 (2016).

Preclincial evaluation of Gold-DTDTPA Nanoparticles As Theranostic Agents In Prostate Cancer Radiotherapy. Nanomedicine 10.2217/nn, 2035-2047 (2016).

Taggart, L. E. et al. and Cytotoxicity of 1 . 9 Nm Gold Nanoparticles. 2673-2685 (2012).

Iversen, T. G., Skotland, T. & Sandvig, K. Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano Today 6, 176-185 (2011). [OpenAIRE]

Chithrani, B. D. & Chan, W. C. W. Elucidating the mechanism of cellular uptake and removal of proteincoated gold nanoparticles of different sizes and shapes. Nano Lett. 7, 1542-1550 (2007). [OpenAIRE]

46 references, page 1 of 4
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue