Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells

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Venere, M.; Hamerlik, P.; Wu, Q.; Rasmussen, R. D.; Song, L. A.; Vasanji, A.; Tenley, N.; Flavahan, W. A.; Hjelmeland, A. B.; Bartek, J.; Rich, J. N.;

Glioblastoma-initiating cells (GICs) are self-renewing tumorigenic sub-populations, contributing to therapeutic resistance via decreased sensitivity to ionizing radiation (IR). GIC survival following IR is attributed to an augmented response to genotoxic stress. We now ... View more
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