Mutation of exposed hydrophobic amino acids to arginine to increase protein stability

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Strub, Caroline; Alies, Carole; Lougarre, Andrée; Ladurantie, Caroline; Czaplicki, Jerzy; Fournier, Didier;

<p>Abstract</p> <p>Background</p> <p>One strategy to increase the stability of proteins is to reduce the area of water-accessible hydrophobic surface.</p> <p>Results</p> <p>In order to test it, we replaced 14 solvent-exposed hydrophobic residues of acetylcholinesterase ... View more
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