publication . Article . Other literature type . 2018

Chemoresistance and the Self-Maintaining Tumor Microenvironment.

Yeldag, G; Rice, A; Del Rio Hernandez, A;
Open Access English
  • Published: 01 Nov 2018 Journal: Cancers, volume 10, issue 12 (eissn: 2072-6694, Copyright policy)
  • Publisher: MDPI
  • Country: United Kingdom
Abstract
<jats:p>The progression of cancer is associated with alterations in the tumor microenvironment, including changes in extracellular matrix (ECM) composition, matrix rigidity, hypervascularization, hypoxia, and paracrine factors. One key malignant phenotype of cancer cells is their ability to resist chemotherapeutics, and elements of the ECM can promote chemoresistance in cancer cells through a variety of signaling pathways, inducing changes in gene expression and protein activity that allow resistance. Furthermore, the ECM is maintained as an environment that facilitates chemoresistance, since its constitution modulates the phenotype of cancer-associated cells, w...
Subjects
free text keywords: Review, chemoresistance, ECM, fibrosis, hypoxia, mechanosignaling, paracrine, hypervascularization, cancer stem cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Science & Technology, Life Sciences & Biomedicine, Oncology, EPITHELIAL-MESENCHYMAL TRANSITION, CANCER-ASSOCIATED FIBROBLASTS, GROWTH-FACTOR-BETA, INTERSTITIAL FLUID PRESSURE, NF-KAPPA-B, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, ACTIVATED PROTEIN-KINASE, EXTRACELLULAR-MATRIX, BREAST-CANCER, TGF-BETA, Cancer research, Cancer cell, Signal transduction, Immunology, Paracrine signalling, Gene expression, Extracellular matrix, Medicine, business.industry, business, Phenotype, Tumor microenvironment, Cancer, medicine.disease
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247 references, page 1 of 17

Zheng, H.. The molecular mechanisms of chemoresistance in cancers. Oncotarget. 2017; 8: 59950-59964 [OpenAIRE] [PubMed] [DOI]

Senthebane, D.A., Rowe, A., Thomford, N.E., Shipanga, H., Munro, D., Mazeedi, M., Almazyadi, H.A.M., Kallmeyer, K., Dandara, C., Pepper, M.S.. The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer. Int. J. Mol. Sci.. 2017; 18 [OpenAIRE] [PubMed] [DOI]

Cox, T.R., Erler, J.T.. Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer. Dis. Model. Mech.. 2011; 4: 165-178 [OpenAIRE] [PubMed] [DOI]

Zhang, X., Nie, D., Chakrabarty, S.. Growth factors in tumor microenvironment. Front. Biosci.. 2012; 15: 151-165 [OpenAIRE] [DOI]

Petrova, V., Annicchiarico-Petruzzelli, M., Melino, G., Amelio, I.. The hypoxic tumour microenvironment. Oncogenesis. 2018; 7: 10 [OpenAIRE] [PubMed] [DOI]

Chorawala, M., Oza, P., Shah, G.. Mechanisms of Anticancer Drugs Resistance: An Overview. Int. J. Pharm. Sci. Drug Res.. 2012; 4: 1-9 [OpenAIRE] [DOI]

Dzobo, K., Senthebane, D.A., Rowe, A., Thomford, N.E., Mwapagha, L.M., Al-Awwad, N., Dandara, C., Parker, M.I.. Cancer Stem Cell Hypothesis for Therapeutic Innovation in Clinical Oncology? Taking the Root Out, Not Chopping the Leaf. OMICS. 2016; 20: 681-691 [OpenAIRE] [PubMed] [DOI]

Zhao, J.. Cancer stem cells and chemoresistance: The smartest survives the raid. Pharmacol. Ther.. 2016; 160: 145-158 [OpenAIRE] [PubMed] [DOI]

Tan, Q., Saggar, J.K., Yu, M., Wang, M., Tannock, I.F.. Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them. Cancer J.. 2015; 21: 254-262 [PubMed] [DOI]

Stylianopoulos, T., Poh, M.Z., Insin, N., Bawendi, M.G., Fukumura, D., Munn, L.L., Jain, R.K.. Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions. Biophys. J.. 2010; 99: 1342-1349 [OpenAIRE] [PubMed] [DOI]

Tannock, I.F., Rotin, D.. Acid pH in Tumors and Its Potential for Therapeutic Exploitation. Cancer Res.. 1989; 49: 4973-4384

Michael, M., Doherty, M.M.. Tumoral drug metabolism: Overview and its implications for cancer therapy. J. Clin. Oncol.. 2005; 23: 205-229 [PubMed] [DOI]

Fletcher, J.I., Haber, M., Henderson, M.J., Norris, M.D.. ABC transporters in cancer: More than just drug efflux pumps. Nat. Rev. Cancer. 2010; 10: 147-156 [OpenAIRE] [PubMed] [DOI]

Xue, X., Liang, X.. Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology. Chin. J. Cancer. 2012; 31: 100-109 [OpenAIRE] [PubMed] [DOI]

Krishna, R., Mayer, L.D.. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci.. 2000; 11: 265-283 [PubMed] [DOI]

247 references, page 1 of 17
Abstract
<jats:p>The progression of cancer is associated with alterations in the tumor microenvironment, including changes in extracellular matrix (ECM) composition, matrix rigidity, hypervascularization, hypoxia, and paracrine factors. One key malignant phenotype of cancer cells is their ability to resist chemotherapeutics, and elements of the ECM can promote chemoresistance in cancer cells through a variety of signaling pathways, inducing changes in gene expression and protein activity that allow resistance. Furthermore, the ECM is maintained as an environment that facilitates chemoresistance, since its constitution modulates the phenotype of cancer-associated cells, w...
Subjects
free text keywords: Review, chemoresistance, ECM, fibrosis, hypoxia, mechanosignaling, paracrine, hypervascularization, cancer stem cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Science & Technology, Life Sciences & Biomedicine, Oncology, EPITHELIAL-MESENCHYMAL TRANSITION, CANCER-ASSOCIATED FIBROBLASTS, GROWTH-FACTOR-BETA, INTERSTITIAL FLUID PRESSURE, NF-KAPPA-B, HYPOXIA-INDUCIBLE FACTOR-1-ALPHA, ACTIVATED PROTEIN-KINASE, EXTRACELLULAR-MATRIX, BREAST-CANCER, TGF-BETA, Cancer research, Cancer cell, Signal transduction, Immunology, Paracrine signalling, Gene expression, Extracellular matrix, Medicine, business.industry, business, Phenotype, Tumor microenvironment, Cancer, medicine.disease
Related Organizations
Download fromView all 5 versions
Cancers
Article . 2018
Cancers
Article . 2018
Provider: Crossref
Cancers
Article
Provider: UnpayWall
247 references, page 1 of 17

Zheng, H.. The molecular mechanisms of chemoresistance in cancers. Oncotarget. 2017; 8: 59950-59964 [OpenAIRE] [PubMed] [DOI]

Senthebane, D.A., Rowe, A., Thomford, N.E., Shipanga, H., Munro, D., Mazeedi, M., Almazyadi, H.A.M., Kallmeyer, K., Dandara, C., Pepper, M.S.. The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer. Int. J. Mol. Sci.. 2017; 18 [OpenAIRE] [PubMed] [DOI]

Cox, T.R., Erler, J.T.. Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer. Dis. Model. Mech.. 2011; 4: 165-178 [OpenAIRE] [PubMed] [DOI]

Zhang, X., Nie, D., Chakrabarty, S.. Growth factors in tumor microenvironment. Front. Biosci.. 2012; 15: 151-165 [OpenAIRE] [DOI]

Petrova, V., Annicchiarico-Petruzzelli, M., Melino, G., Amelio, I.. The hypoxic tumour microenvironment. Oncogenesis. 2018; 7: 10 [OpenAIRE] [PubMed] [DOI]

Chorawala, M., Oza, P., Shah, G.. Mechanisms of Anticancer Drugs Resistance: An Overview. Int. J. Pharm. Sci. Drug Res.. 2012; 4: 1-9 [OpenAIRE] [DOI]

Dzobo, K., Senthebane, D.A., Rowe, A., Thomford, N.E., Mwapagha, L.M., Al-Awwad, N., Dandara, C., Parker, M.I.. Cancer Stem Cell Hypothesis for Therapeutic Innovation in Clinical Oncology? Taking the Root Out, Not Chopping the Leaf. OMICS. 2016; 20: 681-691 [OpenAIRE] [PubMed] [DOI]

Zhao, J.. Cancer stem cells and chemoresistance: The smartest survives the raid. Pharmacol. Ther.. 2016; 160: 145-158 [OpenAIRE] [PubMed] [DOI]

Tan, Q., Saggar, J.K., Yu, M., Wang, M., Tannock, I.F.. Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them. Cancer J.. 2015; 21: 254-262 [PubMed] [DOI]

Stylianopoulos, T., Poh, M.Z., Insin, N., Bawendi, M.G., Fukumura, D., Munn, L.L., Jain, R.K.. Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions. Biophys. J.. 2010; 99: 1342-1349 [OpenAIRE] [PubMed] [DOI]

Tannock, I.F., Rotin, D.. Acid pH in Tumors and Its Potential for Therapeutic Exploitation. Cancer Res.. 1989; 49: 4973-4384

Michael, M., Doherty, M.M.. Tumoral drug metabolism: Overview and its implications for cancer therapy. J. Clin. Oncol.. 2005; 23: 205-229 [PubMed] [DOI]

Fletcher, J.I., Haber, M., Henderson, M.J., Norris, M.D.. ABC transporters in cancer: More than just drug efflux pumps. Nat. Rev. Cancer. 2010; 10: 147-156 [OpenAIRE] [PubMed] [DOI]

Xue, X., Liang, X.. Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology. Chin. J. Cancer. 2012; 31: 100-109 [OpenAIRE] [PubMed] [DOI]

Krishna, R., Mayer, L.D.. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci.. 2000; 11: 265-283 [PubMed] [DOI]

247 references, page 1 of 17
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publication . Article . Other literature type . 2018

Chemoresistance and the Self-Maintaining Tumor Microenvironment.

Yeldag, G; Rice, A; Del Rio Hernandez, A;