publication . Article . Other literature type . 2015

The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents

Anderson, Emma L; Howe, Laura D; Jones, Hayley E; Higgins, Julian P T; Lawlor, Debbie A; Fraser, Abigail;
Open Access English
  • Published: 29 Oct 2015 Journal: PLoS ONE, volume 10, issue 10 (eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
  • Country: United Kingdom
Abstract
<p>BACKGROUND &amp; AIMS: Narrative reviews of paediatric NAFLD quote prevalences in the general population that range from 9% to 37%; however, no systematic review of the prevalence of NAFLD in children/adolescents has been conducted. We aimed to estimate prevalence of non-alcoholic fatty liver disease (NAFLD) in young people and to determine whether this varies by BMI category, gender, age, diagnostic method, geographical region and study sample size.</p><p>METHODS: We conducted a systematic review and meta-analysis of all studies reporting a prevalence of NAFLD based on any diagnostic method in participants 1-19 years old, regardless of whether assessing NAFL...
Subjects
free text keywords: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418, Meta-Analysis, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016454, Review, Research Article, Medicine, R, Science, Q, Internal medicine, medicine.medical_specialty, business.industry, business, Alcoholic fatty liver, Gastroenterology, Disease
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31 references, page 1 of 3

1 Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol 2009;8 Suppl 1:S4–S8. 19381118 [PubMed]

2 Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:370–379. 10.1055/s-0028-1091981 18956293 [OpenAIRE] [PubMed] [DOI]

3 Leevy CM. Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature. Medicine (Baltimore)1962;41:249–276.14463641 [PubMed]

4 Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of Fatty Liver in Children and Adolescents. Pediatrics 2006;118:1388–1393. 17015527 [OpenAIRE] [PubMed]

5 Wieckowska A, Feldstein AE. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis 2008;28:386–395. 10.1055/s-0028-1091983 18956295 [OpenAIRE] [PubMed] [DOI]

6 Kim D, Kim WR, Kim HJ, Therneau TM. Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States. Hepatology 2013;57:1357–1365. 10.1002/hep.26156 23175136 [OpenAIRE] [PubMed] [DOI]

7 Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010;53:372–384. 10.1016/j.jhep.2010.04.008 20494470 [OpenAIRE] [PubMed] [DOI]

8 Goldberg DM. Structural, functional, and clinical aspects of gamma-glutamyltransferase. CRC Crit Rev Clin Lab Sci 1980;12:1–58. 6104563 [PubMed]

9 Lott J, Olf P. Alanine and aspartate aminotransferase (ALT and AST)Clinical enzymology: a case-oriented approach. Chicago: Year Book Medical Publishers, 1986:111–138.

10 Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton MS, Kerkar N et al SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease. Gastroenterology 2010;138:1357–1364. 10.1053/j.gastro.2009.12.052 20064512 [OpenAIRE] [PubMed] [DOI]

11 Park HN, Sinn DH, Gwak GY, Kim JE, Rhee SY, Eo SJ et al Upper normal threshold of serum alanine aminotransferase in identifying individuals at risk for chronic liver disease. Liver Int 2012;32:937–944. 10.1111/j.1478-3231.2011.02749.x 22260521 [OpenAIRE] [PubMed] [DOI]

12 Lockitch G, Halste ad AC, Albersheim S, MacCallum C, Quigley G. Age- and sex-specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer. Clin Chem 1988;34:1622–1625. 3402068 [OpenAIRE] [PubMed]

13 Zheng MH, Shi KQ, Fan YC, Liu WY, Lin XF, Li LF et al Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population. PLoS One 2012;7:e43736 10.1371/journal.pone.0043736 22962588 [OpenAIRE] [PubMed] [DOI]

14 Prati D, Taioli E, Zanella A, Della TE, Butelli S, Del VE et al Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002;137:1–10. 12093239 [OpenAIRE] [PubMed]

15 Fishbein MH, Miner M, Mogren C, Chalekson J. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. Journal of Pediatric Gastroenterology and Nutrition 2003;2002/12/25:54–61. 12499997 [PubMed]

31 references, page 1 of 3
Abstract
<p>BACKGROUND &amp; AIMS: Narrative reviews of paediatric NAFLD quote prevalences in the general population that range from 9% to 37%; however, no systematic review of the prevalence of NAFLD in children/adolescents has been conducted. We aimed to estimate prevalence of non-alcoholic fatty liver disease (NAFLD) in young people and to determine whether this varies by BMI category, gender, age, diagnostic method, geographical region and study sample size.</p><p>METHODS: We conducted a systematic review and meta-analysis of all studies reporting a prevalence of NAFLD based on any diagnostic method in participants 1-19 years old, regardless of whether assessing NAFL...
Subjects
free text keywords: /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428, Journal Article, /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418, Meta-Analysis, /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485, Research Support, Non-U.S. Gov't, /dk/atira/pure/researchoutput/pubmedpublicationtype/D016454, Review, Research Article, Medicine, R, Science, Q, Internal medicine, medicine.medical_specialty, business.industry, business, Alcoholic fatty liver, Gastroenterology, Disease
Download fromView all 5 versions
PLoS ONE
Article . 2015
PLoS ONE
Article . 2015
Provider: Crossref
PLoS ONE
Article
Provider: UnpayWall
31 references, page 1 of 3

1 Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol 2009;8 Suppl 1:S4–S8. 19381118 [PubMed]

2 Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 2008;28:370–379. 10.1055/s-0028-1091981 18956293 [OpenAIRE] [PubMed] [DOI]

3 Leevy CM. Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature. Medicine (Baltimore)1962;41:249–276.14463641 [PubMed]

4 Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of Fatty Liver in Children and Adolescents. Pediatrics 2006;118:1388–1393. 17015527 [OpenAIRE] [PubMed]

5 Wieckowska A, Feldstein AE. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin Liver Dis 2008;28:386–395. 10.1055/s-0028-1091983 18956295 [OpenAIRE] [PubMed] [DOI]

6 Kim D, Kim WR, Kim HJ, Therneau TM. Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States. Hepatology 2013;57:1357–1365. 10.1002/hep.26156 23175136 [OpenAIRE] [PubMed] [DOI]

7 Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol 2010;53:372–384. 10.1016/j.jhep.2010.04.008 20494470 [OpenAIRE] [PubMed] [DOI]

8 Goldberg DM. Structural, functional, and clinical aspects of gamma-glutamyltransferase. CRC Crit Rev Clin Lab Sci 1980;12:1–58. 6104563 [PubMed]

9 Lott J, Olf P. Alanine and aspartate aminotransferase (ALT and AST)Clinical enzymology: a case-oriented approach. Chicago: Year Book Medical Publishers, 1986:111–138.

10 Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton MS, Kerkar N et al SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease. Gastroenterology 2010;138:1357–1364. 10.1053/j.gastro.2009.12.052 20064512 [OpenAIRE] [PubMed] [DOI]

11 Park HN, Sinn DH, Gwak GY, Kim JE, Rhee SY, Eo SJ et al Upper normal threshold of serum alanine aminotransferase in identifying individuals at risk for chronic liver disease. Liver Int 2012;32:937–944. 10.1111/j.1478-3231.2011.02749.x 22260521 [OpenAIRE] [PubMed] [DOI]

12 Lockitch G, Halste ad AC, Albersheim S, MacCallum C, Quigley G. Age- and sex-specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer. Clin Chem 1988;34:1622–1625. 3402068 [OpenAIRE] [PubMed]

13 Zheng MH, Shi KQ, Fan YC, Liu WY, Lin XF, Li LF et al Upper limits of normal for serum alanine aminotransferase levels in Chinese Han population. PLoS One 2012;7:e43736 10.1371/journal.pone.0043736 22962588 [OpenAIRE] [PubMed] [DOI]

14 Prati D, Taioli E, Zanella A, Della TE, Butelli S, Del VE et al Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002;137:1–10. 12093239 [OpenAIRE] [PubMed]

15 Fishbein MH, Miner M, Mogren C, Chalekson J. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. Journal of Pediatric Gastroenterology and Nutrition 2003;2002/12/25:54–61. 12499997 [PubMed]

31 references, page 1 of 3
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