FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness

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Campbell, Thomas; Castro, Mauro AA; de, Santiago Ines; Fletcher, Michael NC; Halim, Silvia; Prathalingam, Radhika; Ponder, Bruce; Meyer, Kerstin;

The fibroblast growth factor receptor 2 (FGFR2) locus is consistently the top hit in genome-wide association studies for oestrogen receptor-positive (ER+) breast cancer. Yet, its mode of action continues to be controversial. Here, we employ a systems biology approach to... View more
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