A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix
- Publisher: Nature Publishing Group
(issn: 2045-2322, eissn: 2045-2322)
mesheuropmc: digestive system | surgical procedures, operative | digestive system diseases | neoplasms
Many tumors over-express collagen, which constitutes the physical scaffold of tumor microenvironment. Collagen has been considered to be a target for cancer therapy. The collagen-binding domain (CBD) is a short peptide, which could bind to collagen and achieve the susta...