A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix

Article English OPEN
Liang, Hui ; Li, Xiaoran ; Wang, Bin ; Chen, Bing ; Zhao, Yannan ; Sun, Jie ; Zhuang, Yan ; Shi, Jiajia ; Shen, He ; Zhang, Zhijun ; Dai, Jianwu (2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep18205, pmc: PMC4756367
  • Subject: Article
    mesheuropmc: digestive system | surgical procedures, operative | digestive system diseases | neoplasms

Many tumors over-express collagen, which constitutes the physical scaffold of tumor microenvironment. Collagen has been considered to be a target for cancer therapy. The collagen-binding domain (CBD) is a short peptide, which could bind to collagen and achieve the susta... View more
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