publication . Article . 2015

Radioiodinated PARP1 tracers for glioblastoma imaging.

Nagavarakishore Pillarsetty; Susanne Kossatz; Wolfgang A. Weber; Wolfgang A. Weber; Christopher Irwin; Thomas Reiner; Thomas Reiner; Alexander Bolaender; Beatriz Salinas; Gabriela Chiosis;
Open Access English
  • Published: 01 Sep 2015 Journal: EJNMMI Research, volume 5, issue 1 (issn: 2191-219X, Copyright policy)
  • Publisher: Springer Nature
Abstract
Background Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part due to difficulties in diagnosing this disease early, combined with its diffuse, infiltrative growth. This study was aimed at the development of a novel diagnostic tool for glioblastoma through the synthesis of a small molecule based on radioiodinated poly(ADP-ribose)polymerase 1 (PARP1) targeted tracers. This PARP1 is a biomarker that is overexpressed in glioblastoma tissue, but has only low expr...
Subjects
free text keywords: Original Research, PARP1, Glioblastoma, 131I, 124I, PET, SPECT, U87 MG, U251 MG, Radiology Nuclear Medicine and imaging, Infiltrative Growth, Pathology, medicine.medical_specialty, medicine, Disease early, Cancer, medicine.disease, Biomarker (medicine), business.industry, business, Treatment options
Related Organizations
Funded by
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Bioorthogonal Strategies for Targeted PET Imaging Probe Development
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K25EB016673-01
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
30 references, page 1 of 2

Wen, PY, Kesari, S. Malignant gliomas in adults. N Engl J Med. 2008; 359: 492-507 [PubMed] [DOI]

Irwin, CP, Portorreal, Y, Brand, C, Zhang, Y, Desai, P, Salinas, B. PARPi-FL—a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014; 16: 432-40 [OpenAIRE] [PubMed] [DOI]

Weissleder, R, Pittet, MJ. Imaging in the era of molecular oncology. Nature. 2008; 452: 580-9 [OpenAIRE] [PubMed] [DOI]

Kalpathy-Cramer, J, Gerstner, ER, Emblem, KE, Andronesi, OC, Rosen, B. Advanced magnetic resonance imaging of the physical processes in human glioblastoma. Cancer Res. 2014; 74: 4622-37 [OpenAIRE] [PubMed] [DOI]

Yoon, J, Kim, J-h, Kang, W, Sohn, C-H, Choi, S, Yun, T. Grading of cerebral glioma with multiparametric MR imaging and 18F-FDG-PET: concordance and accuracy. Eur Radiol. 2014; 24: 380-9 [OpenAIRE] [PubMed] [DOI]

Santra, A, Kumar, R, Sharma, P, Bal, C, Kumar, A, Julka, PK. F-18 FDG PET-CT in patients with recurrent glioma: comparison with contrast enhanced MRI. Eur J Radiol. 2012; 81: 508-13 [OpenAIRE] [PubMed] [DOI]

Sorensen, AG, Batchelor, TT, Wen, PY, Zhang, WT, Jain, RK. Response criteria for glioma. Nat Clin Pract Oncol. 2008; 5: 634-44 [OpenAIRE] [PubMed] [DOI]

Xie, Q, Mittal, S, Berens, ME. Targeting adaptive glioblastoma: an overview of proliferation and invasion. Neurooncology. 2014; 16: 1575-84

Gradwohl, G, Ménissier de Murcia, JM, Molinete, M, Simonin, F, Koken, M, Hoeijmakers, JH. The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc Natl Acad Sci U S A. 1990; 87: 2990-4 [OpenAIRE] [PubMed] [DOI]

Hassa, PO, Hottiger, MO. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2008; 13: 3046-82 [OpenAIRE] [PubMed] [DOI]

Rouleau, M, Patel, A, Hendzel, MJ, Kaufmann, SH, Poirier, GG. PARP inhibition: PARP1 and beyond. Nat Rev Cancer. 2010; 10: 293-301 [OpenAIRE] [PubMed] [DOI]

Kraus, WL, Hottiger, MO. PARP-1 and gene regulation: progress and puzzles. Mol Aspects Med. 2013; 34: 1109-23 [OpenAIRE] [PubMed] [DOI]

Burkle, A, Virag, L. Poly(ADP-ribose): PARadigms and PARadoxes. Mol Aspects Med. 2013; 34: 1046-65 [OpenAIRE] [PubMed] [DOI]

Jagtap, P, Szabo, C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005; 4: 421-40 [PubMed] [DOI]

Schreiber, V, Dantzer, F, Ame, JC, de Murcia, G. Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol. 2006; 7: 517-28 [OpenAIRE] [PubMed] [DOI]

30 references, page 1 of 2
Abstract
Background Although the understanding of the genetic and molecular basis of cancer has advanced significantly over the past several decades, imaging and treatment options for glioblastoma patients have been more limited (N Engl J Med 359:492-507, 2008). This is in part due to difficulties in diagnosing this disease early, combined with its diffuse, infiltrative growth. This study was aimed at the development of a novel diagnostic tool for glioblastoma through the synthesis of a small molecule based on radioiodinated poly(ADP-ribose)polymerase 1 (PARP1) targeted tracers. This PARP1 is a biomarker that is overexpressed in glioblastoma tissue, but has only low expr...
Subjects
free text keywords: Original Research, PARP1, Glioblastoma, 131I, 124I, PET, SPECT, U87 MG, U251 MG, Radiology Nuclear Medicine and imaging, Infiltrative Growth, Pathology, medicine.medical_specialty, medicine, Disease early, Cancer, medicine.disease, Biomarker (medicine), business.industry, business, Treatment options
Related Organizations
Funded by
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Bioorthogonal Strategies for Targeted PET Imaging Probe Development
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K25EB016673-01
  • Funding stream: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
30 references, page 1 of 2

Wen, PY, Kesari, S. Malignant gliomas in adults. N Engl J Med. 2008; 359: 492-507 [PubMed] [DOI]

Irwin, CP, Portorreal, Y, Brand, C, Zhang, Y, Desai, P, Salinas, B. PARPi-FL—a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014; 16: 432-40 [OpenAIRE] [PubMed] [DOI]

Weissleder, R, Pittet, MJ. Imaging in the era of molecular oncology. Nature. 2008; 452: 580-9 [OpenAIRE] [PubMed] [DOI]

Kalpathy-Cramer, J, Gerstner, ER, Emblem, KE, Andronesi, OC, Rosen, B. Advanced magnetic resonance imaging of the physical processes in human glioblastoma. Cancer Res. 2014; 74: 4622-37 [OpenAIRE] [PubMed] [DOI]

Yoon, J, Kim, J-h, Kang, W, Sohn, C-H, Choi, S, Yun, T. Grading of cerebral glioma with multiparametric MR imaging and 18F-FDG-PET: concordance and accuracy. Eur Radiol. 2014; 24: 380-9 [OpenAIRE] [PubMed] [DOI]

Santra, A, Kumar, R, Sharma, P, Bal, C, Kumar, A, Julka, PK. F-18 FDG PET-CT in patients with recurrent glioma: comparison with contrast enhanced MRI. Eur J Radiol. 2012; 81: 508-13 [OpenAIRE] [PubMed] [DOI]

Sorensen, AG, Batchelor, TT, Wen, PY, Zhang, WT, Jain, RK. Response criteria for glioma. Nat Clin Pract Oncol. 2008; 5: 634-44 [OpenAIRE] [PubMed] [DOI]

Xie, Q, Mittal, S, Berens, ME. Targeting adaptive glioblastoma: an overview of proliferation and invasion. Neurooncology. 2014; 16: 1575-84

Gradwohl, G, Ménissier de Murcia, JM, Molinete, M, Simonin, F, Koken, M, Hoeijmakers, JH. The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc Natl Acad Sci U S A. 1990; 87: 2990-4 [OpenAIRE] [PubMed] [DOI]

Hassa, PO, Hottiger, MO. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2008; 13: 3046-82 [OpenAIRE] [PubMed] [DOI]

Rouleau, M, Patel, A, Hendzel, MJ, Kaufmann, SH, Poirier, GG. PARP inhibition: PARP1 and beyond. Nat Rev Cancer. 2010; 10: 293-301 [OpenAIRE] [PubMed] [DOI]

Kraus, WL, Hottiger, MO. PARP-1 and gene regulation: progress and puzzles. Mol Aspects Med. 2013; 34: 1109-23 [OpenAIRE] [PubMed] [DOI]

Burkle, A, Virag, L. Poly(ADP-ribose): PARadigms and PARadoxes. Mol Aspects Med. 2013; 34: 1046-65 [OpenAIRE] [PubMed] [DOI]

Jagtap, P, Szabo, C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005; 4: 421-40 [PubMed] [DOI]

Schreiber, V, Dantzer, F, Ame, JC, de Murcia, G. Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol. 2006; 7: 517-28 [OpenAIRE] [PubMed] [DOI]

30 references, page 1 of 2
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