Global Inhibition of Reactive Oxygen Species (ROS) Inhibits Paclitaxel-Induced Painful Peripheral Neuropathy

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Mehmet Fidanboylu; Lisa A Griffiths; Sarah J L Flatters;
  • Publisher: Public Library of Science
  • Journal: volume 6,issue 9issn: 1932-6203, eissn: 1932-6203
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3180385, doi: 10.1371/journal.pone.0025212
  • Subject: Cancer Treatment | Signaling Cascades | Cellular Stress Responses | Research Article | Molecular Cell Biology | /dk/atira/pure/subjectarea/asjc/1100/1101 | Biochemistry, Genetics and Molecular Biology (miscellaneous) | Oncology | Stress Signaling Cascade | Agricultural and Biological Sciences (miscellaneous) | /dk/atira/pure/subjectarea/asjc/2700/2701 | Medicine (miscellaneous) | Biology | Anesthesiology | Signal Transduction | Neuroscience | Medicine | Pain Management | Drug Research and Development | Q | R | Chemotherapy and Drug Treatment | Drugs and Devices | Science | /dk/atira/pure/subjectarea/asjc/1300/1301 | Behavioral Neuroscience

<p>Paclitaxel (Taxol (R)) is a widely used chemotherapeutic agent that has a major dose limiting side-effect of painful peripheral neuropathy. Currently there is no effective therapy for the prevention or treatment of chemotherapy-induced painful peripheral neuropathies... View more
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