A Genome-wide Association Analysis of a Broad Psychosis Phenotype Identifies Three Loci for Further Investigation

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Bramon, Elvira; Pirinen, Matti; Strange, Amy; Lin, Kuang; Freeman, Colin; Bellenguez, Celine; Su, Zhan; Band, Gavin; Pearson, Richard; Vukcevic, Damjan; Langford, Cordelia; Deloukas, Panos; Hunt, Sarah; Gray, Emma; Dronov, Serge; Potter, Simon C.; Tashakkori-Ghanbaria, Avazeh; Edkins, Sarah; Bumpstead, Suzannah J.; Arranz, Maria J.; Bakker, Steven; Bender, Stephan; Bruggeman, Richard; Cahn, Wiepke; Chandler, David; Collier, David A.; Crespo-Facorro, Benedicto; Dazzan, Paola; de Haan, Lieuwe; di Forti, Marta; ... view all 82 authors
  • Journal: volume 75,issue 5,pages386-397issn: 0006-3223
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  • Related identifiers: doi: 10.1016/j.biopsych.2013.03.033
  • Subject: BIPOLAR-DISORDER | HAN CHINESE | meta-analysis | WINNERS CURSE | schizophrenia | CONFERRING RISK | PSYCHIATRIC-DISORDERS | psychosis | FOLLOW-UP | Bipolar disorder | SUSCEPTIBILITY LOCUS | GENERAL-POPULATION | GENETIC RISK | genome-wide association | polygenic score analysis | COMMON VARIANTS

<p>Background: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories.</p><p>Methods: 1239 cases wi... View more
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    3. Ruderfer DM, Kirov G, Chambert K, Moran JL, Owen MJ, O'Donovan MC, et al. (2011): A familybased study of common polygenic variation and risk of schizophrenia. Mol Psychiatry. 16:887- 888.

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