Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

Article, Preprint OPEN
Baillie, J. Kenneth; Bretherick, Andrew; Haley, Christopher S.; Clohisey, Sara; Gray, Alan; Neyton, Lucile P. A.; Barrett, Jeffrey; Stahl, Eli A.; Tenesa, Albert; Andersson, Robin; Brown, J. Ben; Faulkner, Geoffrey J.; Lizio, Marina; Schaefer, Ulf; Daub, Carsten; Itoh, Masayoshi; Kondo, Naoto; Lassmann, Timo; Kawai, Jun; Mole, Damian; Bajic, Vladimir B.; Heutink, Peter; Rehli, Michael; Kawaji, Hideya; Sandelin, Albin; Suzuki, Harukazu; Satsangi, Jack; Wells, Christine A.; Hacohen, Nir; Freeman, Thomas C.; ... view all 34 authors
(2018)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Computational Biology,volume 14,issue 3,pages2018 , ' Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease ' , PLoS Computational Biology , vol. 14 , no. 3 , pp. e1005934 . https://doi.org/10.1371/journal.pcbi.1005934-2018 , ' Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease ' , PLoS Computational Biology , vol. 14 , no. 3 , pp. e1005934 . https://doi.org/10.1371/journal.pcbi.1005934 (issn: 1553-734X, eissn: 1553-7358)
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  • Related identifiers: doi: 10.1371/journal.pcbi.1005934, doi: 10.1101/095349, pmc: PMC5849332
  • Subject: Computational Biology | Human Genetics | Research Article | Colitis | Mathematics | Clinical Medicine | bepress|Life Sciences|Genetics and Genomics|Genomics | Genetics | Physical Sciences | Genome Analysis | Genomics | Ulcerative Colitis | Immunology | Combinatorics | Permutation | Autoimmune Diseases | Biology and Life Sciences | Genetics of Disease | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | Gastroenterology and Hepatology | Signal Transduction | Inflammatory Bowel Disease | QH301-705.5 | bepress|Life Sciences|Biology | Transcriptional Control | Cell Biology | Gene Regulation | Clinical Immunology | Cell Signaling | Journal Article | Medicine and Health Sciences | Genomic Signal Processing | Genome-Wide Association Studies | Gene Expression | Discrete Mathematics | Biology (General) | Crohn's Disease

<p>Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share... View more