Optimal design of experiments for excipient compatibility studies

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Akkermans, Wannes; Coppenolle, Hans; Goos, Peter;
  • Publisher: Elsevier Science Pub. Co.
  • Journal: Chemometrics and intelligent laboratory systems (issn: 0169-7439)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/J.CHEMOLAB.2017.09.012
  • Subject: Chemistry | Randomization restriction | I-optimal design | Mathematics | Physics | Strip-plot design | Mixture-process variable experiment | Split-plot design | D-optimal design | Computer. Automation

Abstract: A crucial stage in the development of medical drugs is to study which additives, usually called excipients, impact the active ingredient stability. This type of study is generally named an excipient compatibility study and requires a mixture experiment. Subseq... View more
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