publication . Other literature type . Patent . Article . Preprint . 2013

Ancient human genomes suggest three ancestral populations for present-day Europeans

Vaidutis Kucinskas;
  • Published: 23 Dec 2013
  • Publisher: Springer Science and Business Media LLC
Abstract
J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundatio...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Genoma humà, Genètica de poblacions humanes, GENOMICS, HUMAN ORIGINS, EUROPE, Otras Ciencias Biológicas, Ciencias Biológicas, CIENCIAS NATURALES Y EXACTAS, Biología, Evolutionary biology, Biology, Genetics, Genetic diversity, Population, education.field_of_study, education, Neanderthal, biology.animal, Human genome, Ancient DNA, Present day, Denisovan, biology.organism_classification, Genome human, Upper Paleolithic, Genome, Quantitative Biology - Populations and Evolution, 410 Linguistics, ancient DNA, modern DNA, Europeans, prehistory, Settore BIO/13 - Biologia Applicata, Article
Funded by
NIH| Population mixture in evolutionary and medical genetics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01GM100233-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NSF| A new history and geography of human genes informed by ancient DNA
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1032255
  • Funding stream: Directorate for Social, Behavioral & Economic Sciences | Division of Behavioral and Cognitive Sciences
,
NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 0827436
  • Funding stream: Directorate for Social, Behavioral & Economic Sciences | Division of Behavioral and Cognitive Sciences
,
NSF| XSEDE: eXtreme Science and Engineering Discovery Environment
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1053575
  • Funding stream: Directorate for Computer & Information Science & Engineering | Division of Advanced Cyberinfrastructure
,
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
69 references, page 1 of 5

Keller, A. New insights into the Tyrolean Iceman’s origin and phenotype as inferred by whole-genome sequencing. Nat Commun. 2012; 3: 698 [OpenAIRE] [PubMed]

Olalde, I. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014; 507: 225-228 [OpenAIRE] [PubMed]

Raghavan, M. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature. 2014; 505: 87-91 [OpenAIRE] [PubMed]

Skoglund, P. Origins and genetic legacy of Neolithic farmers and hunter-gatherers in Europe. Science. 2012; 336: 466-469 [PubMed]

Bramanti, B. Genetic discontinuity between local hunter-gatherers and Central Europe’s first farmers. Science. 2009; 326: 137-140 [OpenAIRE] [PubMed]

Haak, W. Ancient DNA from European early Neolithic farmers reveals their Near Eastern affinities. PLoS Biol. 2010; 8: e1000536 [OpenAIRE] [PubMed]

Lipson, M. Efficient moment-based inference of admixture parameters and sources of gene flow. Mol Biol Evol. 2013; 30: 1788-1802 [OpenAIRE] [PubMed]

Patterson, N. Ancient admixture in human history. Genetics. 2012; 192: 1065-1093 [OpenAIRE] [PubMed]

Krause, J. A complete mtDNA genome of an early modern human from Kostenki, Russia. Curr Biol. 2010; 20: 231-236 [PubMed]

Sawyer, S, Krause, J, Guschanski, K, Savolainen, V, Pääbo, S. Temporal patterns of nucleotide misincorporations and DNA fragmentation in ancient DNA. PLoS ONE. 2012; 7: e34131 [OpenAIRE] [PubMed]

Haak, W. Ancient DNA from the first European farmers in 7500-Year-old Neolithic sites. Science. 2005; 310: 1016-1018 [PubMed]

Perry, GH. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007; 39: 1256-1260 [OpenAIRE] [PubMed]

Alexander, DH, Novembre, J, Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009; 19: 1655-1664 [OpenAIRE] [PubMed]

Patterson, N, Price, AL, Reich, D. Population structure and eigenanalysis. PLoS Genet. 2006; 2: e190 [OpenAIRE] [PubMed]

Reich, D, Thangaraj, K, Patterson, N, Price, AL, Singh, L. Reconstructing Indian population history. Nature. 2009; 461: 489-494 [OpenAIRE] [PubMed]

69 references, page 1 of 5
Abstract
J. Kr., A.M. and C.P. are grateful for support from DFG grant number KR 4015/1-1, the Carl-Zeiss Foundation and the Baden Württemberg Foundation. S. P., G. R., Q. F., C. F., K. P., S.C. and J.Ke. acknowledge support from the Presidential Innovation Fund of the Max Planck Society. G.R. was supported by an NSERC fellowship. J.G.S. acknowledges use of the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by NSF grant number OCI-1053575. E.B. and O.B. were supported by RFBR grants 13-06-00670, 13-04-01711, 13-04-90420. B.M. was supported by grants OTKA 73430 and 103983. A.Saj. was supported by a Finnish Professor Pool (Paulo Foundatio...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Genoma humà, Genètica de poblacions humanes, GENOMICS, HUMAN ORIGINS, EUROPE, Otras Ciencias Biológicas, Ciencias Biológicas, CIENCIAS NATURALES Y EXACTAS, Biología, Evolutionary biology, Biology, Genetics, Genetic diversity, Population, education.field_of_study, education, Neanderthal, biology.animal, Human genome, Ancient DNA, Present day, Denisovan, biology.organism_classification, Genome human, Upper Paleolithic, Genome, Quantitative Biology - Populations and Evolution, 410 Linguistics, ancient DNA, modern DNA, Europeans, prehistory, Settore BIO/13 - Biologia Applicata, Article
Funded by
NIH| Population mixture in evolutionary and medical genetics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01GM100233-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NSF| A new history and geography of human genes informed by ancient DNA
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1032255
  • Funding stream: Directorate for Social, Behavioral & Economic Sciences | Division of Behavioral and Cognitive Sciences
,
NSF| Collaborative Research: Genetic Bases for the Evolution of Human Diet
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 0827436
  • Funding stream: Directorate for Social, Behavioral & Economic Sciences | Division of Behavioral and Cognitive Sciences
,
NSF| XSEDE: eXtreme Science and Engineering Discovery Environment
Project
  • Funder: National Science Foundation (NSF)
  • Project Code: 1053575
  • Funding stream: Directorate for Computer & Information Science & Engineering | Division of Advanced Cyberinfrastructure
,
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
69 references, page 1 of 5

Keller, A. New insights into the Tyrolean Iceman’s origin and phenotype as inferred by whole-genome sequencing. Nat Commun. 2012; 3: 698 [OpenAIRE] [PubMed]

Olalde, I. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature. 2014; 507: 225-228 [OpenAIRE] [PubMed]

Raghavan, M. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature. 2014; 505: 87-91 [OpenAIRE] [PubMed]

Skoglund, P. Origins and genetic legacy of Neolithic farmers and hunter-gatherers in Europe. Science. 2012; 336: 466-469 [PubMed]

Bramanti, B. Genetic discontinuity between local hunter-gatherers and Central Europe’s first farmers. Science. 2009; 326: 137-140 [OpenAIRE] [PubMed]

Haak, W. Ancient DNA from European early Neolithic farmers reveals their Near Eastern affinities. PLoS Biol. 2010; 8: e1000536 [OpenAIRE] [PubMed]

Lipson, M. Efficient moment-based inference of admixture parameters and sources of gene flow. Mol Biol Evol. 2013; 30: 1788-1802 [OpenAIRE] [PubMed]

Patterson, N. Ancient admixture in human history. Genetics. 2012; 192: 1065-1093 [OpenAIRE] [PubMed]

Krause, J. A complete mtDNA genome of an early modern human from Kostenki, Russia. Curr Biol. 2010; 20: 231-236 [PubMed]

Sawyer, S, Krause, J, Guschanski, K, Savolainen, V, Pääbo, S. Temporal patterns of nucleotide misincorporations and DNA fragmentation in ancient DNA. PLoS ONE. 2012; 7: e34131 [OpenAIRE] [PubMed]

Haak, W. Ancient DNA from the first European farmers in 7500-Year-old Neolithic sites. Science. 2005; 310: 1016-1018 [PubMed]

Perry, GH. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007; 39: 1256-1260 [OpenAIRE] [PubMed]

Alexander, DH, Novembre, J, Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009; 19: 1655-1664 [OpenAIRE] [PubMed]

Patterson, N, Price, AL, Reich, D. Population structure and eigenanalysis. PLoS Genet. 2006; 2: e190 [OpenAIRE] [PubMed]

Reich, D, Thangaraj, K, Patterson, N, Price, AL, Singh, L. Reconstructing Indian population history. Nature. 2009; 461: 489-494 [OpenAIRE] [PubMed]

69 references, page 1 of 5
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publication . Other literature type . Patent . Article . Preprint . 2013

Ancient human genomes suggest three ancestral populations for present-day Europeans

Vaidutis Kucinskas;