Investigation of efficiency of the prodrugs valaciclovir, aciclovir and ganciclovir after application of DCES-HSV-tk suicide gene therapy system for the treatment of CC531 liver metastases model in rats

Doctoral thesis German OPEN
Kratzel, Christine;
(2010)
  • Publisher: Freie Universität Berlin Universitätsbibliothek, Garystr. 39, 14195 Berlin
  • Subject: 630 Landwirtschaft, Veterinärmedizin | 630 Agriculture, Veterinary medicine | Liver | Metastasis | Liposomes | Thymidine Kinase | Gene Therapy
    • ddc: ddc:630
    mesheuropmc: viruses

Liver metastases worsen considerably the prognoses of the patients, who suffer from colorectal cancer. Because of the unsatisfactory efficacy of surgical and chemotherapeutic treatment, there is urgent need for the development of new methods of treatment.The aim of the ... View more
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