Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Article, Other literature type English OPEN
Warrison A. Andrade; Sarika Agarwal; Shunyan Mo; Scott A. Shaffer; Joseph P. Dillard; Tobias Schmidt; Veit Hornung; Katherine A. Fitzgerald; Evelyn A. Kurt-Jones; Douglas T. Golenbock;

The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN) production via TLR4/MD-2. In addition to living freely in the extr... View more
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