publication . Article . 2000

Design of the Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial [ISRCTN19943732]

Bradford, Andrew; Lees, Kennedy;
Open Access English
  • Published: 01 Dec 2000 Journal: Current Controlled Trials in Cardiovascular Medicine, volume 1, issue 3, pages 184-190 (issn: 1468-6708, eissn: 1468-6694, Copyright policy)
  • Publisher: BMC
<p>Abstract</p> <p>The Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial is a multicentre,randomised, placebo-controlled trial of magnesium sulphate (MgSO<sub>4</sub>) funded by the UK Medical Research Council. When complete, it will be the largest single neuroprotective study undertaken to date. Conscious patients presenting within 12 h of acute stroke with limb weakness are eligible. The primary outcome measure is combined death and disability as measured using the Barthel Index at 90-day follow up. By randomizing 2700 patients, the study will have 84% power to detect a 5.5% absolute reduction in the primary end-point. By April 2000, 86 centres wer...
free text keywords: IMAGES, acute stroke, magnesium sulphate, R5-920, neuroprotection, Medicine (General), Research
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publication . Article . 2000

Design of the Intravenous Magnesium Efficacy in Acute Stroke (IMAGES) trial [ISRCTN19943732]

Bradford, Andrew; Lees, Kennedy;