Skeletal Adaptation to Intramedullary Pressure-Induced Interstitial Fluid Flow Is Enhanced in Mice Subjected to Targeted Osteocyte Ablation

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Ronald Y Kwon; Diana R Meays; Alexander S Meilan; Jeremiah Jones; Rosa Miramontes; Natalie Kardos; Jiunn-Chern Yeh; John A Frangos;

Interstitial fluid flow (IFF) is a potent regulatory signal in bone. During mechanical loading, IFF is generated through two distinct mechanisms that result in spatially distinct flow profiles: poroelastic interactions within the lacunar-canalicular system, and intramed... View more
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