Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.

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Mongrain, V.; La Spada, F.; Curie, T.; Franken, P.;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 6, issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3200344, doi: 10.1371/journal.pone.0026622
  • Subject: DNA-binding proteins | Sleep Disorders | Research Article | Biology | Medicine | Anatomy and Physiology | Central Nervous System | Sleep | Q | DNA transcription | R | Genetics | Chronobiology | Proteins | Biochemistry | Science | Physiological Processes | Neurological System | Gene expression | Neurology
    mesheuropmc: endocrine system

We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the markers of sleep homeostasis and an increase in homeostatic sleep drive alters clock gene expression in the forebr... View more