Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity

Article, Other literature type English OPEN
Mori, Shogo ; Williams, Howard ; Cagle, Davey ; Karanovich, Kristopher ; Horgen, F. ; III, Roger ; Watanabe, Coran (2015)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Marine Drugs, volume 13, issue 10, pages 6,274-6,290 (issn: 1660-3397, eissn: 1660-3397)
  • Related identifiers: doi: 10.3390/md13106274, pmc: PMC4626689
  • Subject: cell cycle | polyketide | cyanobacteria | macrolactone | Article | Biology (General) | chemotaxis | QH301-705.5

A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural product exhibits anti-chemotactic activity at concentrations as low as 1.3 μM against Jurkat cells, cancerous T lymph... View more
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