Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice

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Ito, Hiroki; Chakrabarty, Basu; Drake, Marcus J; Fry, Christopher H; Kanai, Anthony J; Pickering, Anthony E;
  • Publisher: John Wiley and Sons Inc.
  • Journal: Bju International, volume 124, issue 1, pages 163-173 (issn: 1464-4096, eissn: 1464-410X)
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  • Related identifiers: doi: 10.1111/bju.14664, pmc: PMC6579678
  • Subject: external sphincter function | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | phosphodiesterase type 5 | /dk/atira/pure/core/keywords/centre_for_surgical_research | Journal Article | Sildenafil | lower urinary tract | mice | Translational Science | Centre for Surgical Research

<p>OBJECTIVES: To investigate the influence of low dose phosphodiesterase type 5 inhibitors (PDE5-I) on the function of the mouse lower urinary tract (LUT).</p><p>MATERIALS AND METHODS: Adult male mice were decerebrated and arterially-perfused with a carbogenated Ringer... View more
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