Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

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Walter Jochen; Dewachter Ilse; Dumitrescu-Ozimek Lucia; Sastre Magdalena; Heneka Michael T; Klockgether Thomas; Van Leuven Fred;

<p>Abstract</p> <p>Background</p> <p>Inflammation is suspected to contribute to the progression and severity of neurodegeneration in Alzheimer's disease (AD). Transgenic mice overexpressing the london mutant of amyloid precursor protein, APP [V717I], robustly recapitula... View more
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