publication . Article . Other literature type . 2018

Genome-wide linkage scan for loci influencing plasma triglyceride levels

Peralta, Juan M.; Blackburn, Nicholas B.; Porto, Arthur; Blangero, John; Charlesworth, Jac;
Open Access English
  • Published: 01 Sep 2018 Journal: BMC Proceedings (issn: 1753-6561, Copyright policy)
  • Publisher: BMC
Abstract
Abstract We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic compon...
Subjects
free text keywords: Medicine, R, Science, Q, Proceedings, General Biochemistry, Genetics and Molecular Biology, General Medicine, Endocrinology, medicine.medical_specialty, Genetics, Triglyceride, chemistry.chemical_compound, chemistry, Genome, Internal medicine, Genotype, Fenofibrate, medicine.drug, Genetic linkage, Chromosome, business.industry, business, Locus (genetics), Plasma triglyceride
Related Organizations
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

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