Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster

Article OPEN
Simoni, A; Siniscalchi, C; Chan, Y-S; Huen, DS; Russell, S; Windbichler, N; Crisanti, A;
(2014)
  • Publisher: Oxford University Press
  • Journal: Nucleic Acids Research,volume 42,issue 11,pages7,461-7,472 (issn: 0305-1048, eissn: 1362-4962)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4066794, pmc: PMC4357718, doi: 10.1093/nar/gku387, doi: 10.1093/nar/gkv117
  • Subject: ZFN | BIOCHEMISTRY & MOLECULAR BIOLOGY | 06 Biological Sciences | Drosophila melanogaster | 05 Environmental Sciences | TOOLS | 08 Information And Computing Sciences | TALENS | Homologous Recombination | Corrigendum | DNA | DESIGN | VECTOR | Animals | Female | Life Sciences & Biomedicine | GENES | Developmental Biology | Endodeoxyribonucleases | Synthetic Biology and Chemistry | GENOME | TRANSGENESIS | Protein Engineering | Science & Technology | DNA End-Joining Repair | Male
    mesheuropmc: fungi

Selfish genes are DNA elements that increase their rate of genetic transmission at the expense of other genes in the genome and can therefore quickly spread within a population. It has been suggested that selfish elements could be exploited to modify the genome of entir... View more
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