Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: The GUARDIAN (Genetics underlying diabetes in Hispanics) consortium

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Palmer, ND ; Goodarzi, MO ; Langefeld, CD ; Wang, N ; Guo, X ; Taylor, KD ; Fingerlin, TE ; Norris, JM ; Buchanan, TA ; Xiang, AH ; Haritunians, T ; Ziegler, JT ; Williams, AH ; Stefanovski, D ; Cui, J ; Mackay, AW ; Henkin, LF ; Bergman, RN ; Gao, X ; Gauderman, J ; Varma, R ; Hanis, CL ; Cox, NJ ; Highland, HM ; Below, JE ; Williams, AL ; Burtt, NP ; Aguilar-Salinas, CA ; Huerta-Chagoya, A ; Gonzalez-Villalpando, C ... view all 49 authors (2015)
  • Publisher: eScholarship, University of California
  • Journal: volume 64, issue 5, pages 1,853-1,866 (issn: 0012-1797, eissn: 1939-327X)
  • Related identifiers: pmc: PMC4407862, doi: 10.2337/db14-0732
  • Subject: Genetics/Genomes/Proteomics/Metabolomics
    mesheuropmc: endocrine system diseases | nutritional and metabolic diseases

© 2015 by the American Diabetes Association. Insulin sensitivity, insulin secretion, insulin clearance, and glucose effectiveness exhibit strong genetic components, although few studies have examined their genetic architecture or influence on type 2 diabetes (T2D) risk.... View more