Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect

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Compan, Vincent; Pierredon, Sandra; Vanderperre, Benoît; Krznar, Petra; Marchiq, Ibtissam; Zamboni, Nicola; Pouyssegur, Jacques; Martinou, Jean-Claude;
(2015)
  • Publisher: Elsevier BV
  • Journal: Molecular Cell,volume 59,issue 3,pages491-501 (issn: 1097-2765)
  • Related identifiers: doi: 10.1016/j.molcel.2015.06.035
  • Subject: Molecular Biology | Cell Biology | [SDV]Life Sciences [q-bio]
    mesheuropmc: immune system diseases

International audience; The transport of pyruvate into mitochondria requires a specific carrier, the mitochondrial pyruvate carrier (MPC). The MPC represents a central node of carbon metabolism, and its activity is likely to play a key role in bioenergetics. Until now, ... View more
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