Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells

Article, Other literature type English OPEN
(2014)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: International Journal of Molecular Sciences, volume 15, issue 8, pages 14,555-14,573 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC4159868, doi: 10.3390/ijms150814555
  • Subject: chondroprogenitor | Chemistry | matrilin-3 | spondyloepimetaphyseal dysplasia | QD1-999 | chondrogenesis | TGF-β | multiple epiphyseal dysplasia | Article | Biology (General) | QH301-705.5

Studies have shown that mutations in the matrilin-3 gene (MATN3) are associated with multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). We tested whether MATN3 mutations affect the differentiation of chondroprogenitor and/or mesenchymal ste... View more