publication . Article . 2014

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

Llewellyn, D.; de Cassan, S. C.; Williams, A. R.; Douglas, A. D.; Forbes, E. K.; Adame-Gallegos, J. R.; Shi, J.; Pleass, R. J.; Draper, S. J.;
Open Access English
  • Published: 01 Feb 2014 Journal: Journal of Leukocyte Biology, volume 95, issue 2, pages 369-382 (issn: 0741-5400, eissn: 1938-3673, Copyright policy)
  • Publisher: Society for Leukocyte Biology
Abstract
New tools are required to expedite the development of an effective vaccine against the blood-stage infection with the human malaria parasite Plasmodium falciparum. This work describes the assessment of the ADRB assay in a mouse model, characterizing the functional interaction between antimalarial serum antibodies and FcRs upon neutrophils. We describe a reproducible, antigen-specific assay, dependent on functional FcR signaling, and show that ADRB activity is induced equally by IgG1 and IgG2a isotypes and is modulated by blocking FcR function. However, following immunization of mice with the blood-stage vaccine candidate antigen MSP142, no measurable ADRB activi...
Subjects
mesheuropmc: parasitic diseases
free text keywords: qx_135, merozoite, Host Defense & Pathophysiology, qw_806, malaria, neutrophil, wc_750, vaccine, wh_200, MSP1, assay, qw_575, ROS, Fc receptor
Funded by
EC| EVIMALAR
Project
EVIMALAR
Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
  • Funder: European Commission (EC)
  • Project Code: 242095
  • Funding stream: FP7 | SP1 | HEALTH
,
RCUK| Clinical and Immunological Evaluation of T cell- and Antibody-Inducing Viral Vector Vaccines against Blood-Stage Malar
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G1000527
  • Funding stream: MRC
,
WT| Human and Veterinary Vaccinology.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 084113
  • Funding stream: Immunology and Infectious Disease ; Immune System in Health and Disease
83 references, page 1 of 6

1. malERA Consultative Group on Vaccines (2011) A research agenda for malaria eradication: vaccines. PLoS Med. 8, e1000398. [OpenAIRE]

2. Goodman, A. L., Draper, S. J. (2010) Blood-stage malaria vaccines-recent progress and future challenges. Ann. Trop. Med. Parasitol. 104, 189 - 211.

3. Sheehy, S. H., Duncan, C. J., Elias, S. C., Choudhary, P., Biswas, S., Halstead, F. D., Collins, K. A., Edwards, N. J., Douglas, A. D., Anagnostou, N. A., et al. (2012) ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans. Mol. Ther. 20, 2355-2368.

4. Spring, M. D., Cummings, J. F., Ockenhouse, C. F., Dutta, S., Reidler, R., Angov, E., Bergmann-Leitner, E., Stewart, V. A., Bittner, S., Juompan, L., et al. (2009) Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A. PLoS One 4, e5254.

5. Ogutu, B. R., Apollo, O. J., McKinney, D., Okoth, W., Siangla, J., Dubovsky, F., Tucker, K., Waitumbi, J. N., Diggs, C., Wittes, J., et al. (2009) Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya. PLoS One 4, e4708. [OpenAIRE]

6. Miller, L. H., Good, M. F., Kaslow, D. C. (1997) The need for assays predictive of protection in development of malaria bloodstage vaccines. Parasitol. Today 13, 46 -47.

7. Stowers, A. W., Miller, L. H. (2001) Are trials in New World monkeys on the critical path for blood-stage malaria vaccine development? Trends Parasitol. 17, 415-419.

8. Cohen, S. I., McGregor, A., Carrington, S. (1961) -Globulin and acquired immunity to human malaria. Nature 192, 733-737.

9. Bouharoun-Tayoun, H., Attanath, P., Sabchareon, A., Chongsuphajaisiddhi, T., Druilhe, P. (1990) Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J. Exp. Med. 172, 1633-1641.

10. Miura, K., Zhou, H., Diouf, A. S., Moretz, E., Fay, M. P., Miller, L. H., Martin, L. B., Pierce, M. A., Ellis, R. D., Mullen, G. E. D., Long, C. A. (2009) Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting Plasmodium falciparum growth, as determined by the in vitro growth inhibition assay. Clin. Vaccine Immunol. 16, 963-968.

11. Duncan, C. A., Hill, V. S., Ellis, R. (2012) Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy? Hum. Vaccin. Immunother. 8, 706 -714.

12. Bergmann-Leitner, E. S., Duncan, E. H., Mullen, G. E., Burge, J. R., Khan, F. C., Long, A., Angov, E., Lyon, J. A. (2006) Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens. Am. J. Trop. Med. Hygiene 75, 437- 442.

13. Thera, M. A., Doumbo, O. K., Coulibaly, D., Laurens, M. B., Ouattara, A., Kone, A. K., Guindo, A. B., Traore, K., Traore, I., Kouriba, B., et al. (2011) A field trial to assess a blood-stage malaria vaccine. N. Engl. J. Med. 365, 1004 -1013. [OpenAIRE]

14. Lunel, F., Druilhe, P. (1989) Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro. Infect. Immun. 57, 2043-2049. [OpenAIRE]

15. Bouharoun-Tayoun, H., Druilhe, P. (1992) Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect. Immun. 60, 1473- 1481. [OpenAIRE]

83 references, page 1 of 6
Abstract
New tools are required to expedite the development of an effective vaccine against the blood-stage infection with the human malaria parasite Plasmodium falciparum. This work describes the assessment of the ADRB assay in a mouse model, characterizing the functional interaction between antimalarial serum antibodies and FcRs upon neutrophils. We describe a reproducible, antigen-specific assay, dependent on functional FcR signaling, and show that ADRB activity is induced equally by IgG1 and IgG2a isotypes and is modulated by blocking FcR function. However, following immunization of mice with the blood-stage vaccine candidate antigen MSP142, no measurable ADRB activi...
Subjects
mesheuropmc: parasitic diseases
free text keywords: qx_135, merozoite, Host Defense & Pathophysiology, qw_806, malaria, neutrophil, wc_750, vaccine, wh_200, MSP1, assay, qw_575, ROS, Fc receptor
Funded by
EC| EVIMALAR
Project
EVIMALAR
Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR).
  • Funder: European Commission (EC)
  • Project Code: 242095
  • Funding stream: FP7 | SP1 | HEALTH
,
RCUK| Clinical and Immunological Evaluation of T cell- and Antibody-Inducing Viral Vector Vaccines against Blood-Stage Malar
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: G1000527
  • Funding stream: MRC
,
WT| Human and Veterinary Vaccinology.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 084113
  • Funding stream: Immunology and Infectious Disease ; Immune System in Health and Disease
83 references, page 1 of 6

1. malERA Consultative Group on Vaccines (2011) A research agenda for malaria eradication: vaccines. PLoS Med. 8, e1000398. [OpenAIRE]

2. Goodman, A. L., Draper, S. J. (2010) Blood-stage malaria vaccines-recent progress and future challenges. Ann. Trop. Med. Parasitol. 104, 189 - 211.

3. Sheehy, S. H., Duncan, C. J., Elias, S. C., Choudhary, P., Biswas, S., Halstead, F. D., Collins, K. A., Edwards, N. J., Douglas, A. D., Anagnostou, N. A., et al. (2012) ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans. Mol. Ther. 20, 2355-2368.

4. Spring, M. D., Cummings, J. F., Ockenhouse, C. F., Dutta, S., Reidler, R., Angov, E., Bergmann-Leitner, E., Stewart, V. A., Bittner, S., Juompan, L., et al. (2009) Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A. PLoS One 4, e5254.

5. Ogutu, B. R., Apollo, O. J., McKinney, D., Okoth, W., Siangla, J., Dubovsky, F., Tucker, K., Waitumbi, J. N., Diggs, C., Wittes, J., et al. (2009) Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya. PLoS One 4, e4708. [OpenAIRE]

6. Miller, L. H., Good, M. F., Kaslow, D. C. (1997) The need for assays predictive of protection in development of malaria bloodstage vaccines. Parasitol. Today 13, 46 -47.

7. Stowers, A. W., Miller, L. H. (2001) Are trials in New World monkeys on the critical path for blood-stage malaria vaccine development? Trends Parasitol. 17, 415-419.

8. Cohen, S. I., McGregor, A., Carrington, S. (1961) -Globulin and acquired immunity to human malaria. Nature 192, 733-737.

9. Bouharoun-Tayoun, H., Attanath, P., Sabchareon, A., Chongsuphajaisiddhi, T., Druilhe, P. (1990) Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J. Exp. Med. 172, 1633-1641.

10. Miura, K., Zhou, H., Diouf, A. S., Moretz, E., Fay, M. P., Miller, L. H., Martin, L. B., Pierce, M. A., Ellis, R. D., Mullen, G. E. D., Long, C. A. (2009) Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting Plasmodium falciparum growth, as determined by the in vitro growth inhibition assay. Clin. Vaccine Immunol. 16, 963-968.

11. Duncan, C. A., Hill, V. S., Ellis, R. (2012) Can growth inhibition assays (GIA) predict blood-stage malaria vaccine efficacy? Hum. Vaccin. Immunother. 8, 706 -714.

12. Bergmann-Leitner, E. S., Duncan, E. H., Mullen, G. E., Burge, J. R., Khan, F. C., Long, A., Angov, E., Lyon, J. A. (2006) Critical evaluation of different methods for measuring the functional activity of antibodies against malaria blood stage antigens. Am. J. Trop. Med. Hygiene 75, 437- 442.

13. Thera, M. A., Doumbo, O. K., Coulibaly, D., Laurens, M. B., Ouattara, A., Kone, A. K., Guindo, A. B., Traore, K., Traore, I., Kouriba, B., et al. (2011) A field trial to assess a blood-stage malaria vaccine. N. Engl. J. Med. 365, 1004 -1013. [OpenAIRE]

14. Lunel, F., Druilhe, P. (1989) Effector cells involved in nonspecific and antibody-dependent mechanisms directed against Plasmodium falciparum blood stages in vitro. Infect. Immun. 57, 2043-2049. [OpenAIRE]

15. Bouharoun-Tayoun, H., Druilhe, P. (1992) Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect. Immun. 60, 1473- 1481. [OpenAIRE]

83 references, page 1 of 6
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publication . Article . 2014

Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome

Llewellyn, D.; de Cassan, S. C.; Williams, A. R.; Douglas, A. D.; Forbes, E. K.; Adame-Gallegos, J. R.; Shi, J.; Pleass, R. J.; Draper, S. J.;