The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

Article English OPEN
Blair, Lily M. ; Feldman, Marcus W. (2015)
  • Publisher: Springer Nature
  • Journal: BMC Genetics, volume 16 (issn: 1471-2156, eissn: 1471-2156)
  • Related identifiers: pmc: PMC4501093, doi: 10.1186/s12863-015-0239-3, doi: 10.13039/100000002
  • Subject: Human disease risk loci | Genetics(clinical) | Research Article | Genetics | Positive selection | Environmental adaptation | Genome-wide association studies | Serial founder effect

Background Demography and environmental adaptation can affect the global distribution of genetic variants and possibly the distribution of disease. Population heterozygosity of single nucleotide polymorphisms has been shown to decrease strongly with distance from Africa... View more
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